| Practical limitations of interstitial thermometry during deep hyperthermia. | |
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MedLine Citation:
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PMID: 9539578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Intratumor thermometry during hyperthermia treatment is considered important for several reasons. The morbidity that we experienced from interstitially placed catheters in deep-seated tumors gave reason to weigh the advantages and disadvantages against each other. METHODS AND MATERIALS: The available thermometry in 215 patients treated with hyperthermia for deep-seated tumors was analyzed with the aim to evaluate practically feasible intratumor measurements. The influence of intratumor measurements on the treatment procedure was assessed. RESULTS: Total 120 catheters were placed interstitially in 78 patients. Over the years, the percentage of patients with interstitial thermometry decreased considerably. Forty-nine catheters could remain in place during the whole hyperthermia treatment series. The remaining catheters had to be removed for more or less severe complications, including one fatal event. In fact, the interstitial catheters caused the most severe treatment-related morbidity. During 188 of the total 859 treatments, at least one interstitial catheter was available for thermometry. Per treatment with catheter(s) in situ, the average number of intratumor measurement sites was 6.9. The value of interstitial thermometry for power steering during treatment, to both optimize intratumor temperature distribution and prevent toxicity, appeared limited. The mean volume of the tumors with interstitial thermometry was 314 cm3, SD 325. In relation to the large tumor volumes, the thermal dose parameters calculated from the available data is considered to be of limited value. CONCLUSION: In view of the possible severe complications and the limited clinical value of the information achieved by interstitially placed thermometry catheters, interstitial thermometry was not found to routinely benefit the individual patient. |
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Authors:
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J van der Zee; J N Peer-Valstar; P J Rietveld; L de Graaf-Strukowska; G C van Rhoon |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 40 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-04-13 Completed Date: 1998-04-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1205-12 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, University Hospital Rotterdam/Daniel den Hoed Cancer Center, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catheters, Indwelling
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adverse effects* Humans Hyperthermia, Induced / instrumentation* Infection / etiology Neoplasms / pathology, therapy* Pain / etiology |
| Comments/Corrections | |
Comment In:
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Int J Radiat Oncol Biol Phys. 1998 Mar 15;40(5):1015-7
[PMID:
9539554
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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