Document Detail


Practical fundamentals of glass, rubber, and plastic sterile packaging systems.
MedLine Citation:
PMID:  20088708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sterile product packaging systems consist of glass, rubber, and plastic materials that are in intimate contact with the formulation. These materials can significantly affect the stability of the formulation. The interaction between the packaging materials and the formulation can also affect the appropriate delivery of the product. Therefore, a parenteral formulation actually consists of the packaging system as well as the product that it contains. However, the majority of formulation development time only considers the product that is contained in the packaging system. Little time is spent studying the interaction of the packaging materials with the contents. Interaction between the packaging and the contents only becomes a concern when problems are encountered. For this reason, there are few scientific publications that describe the available packaging materials, their advantages and disadvantages, and their important product attributes. This article was created as a reference for product development and describes some of the packaging materials and systems that are available for parenteral products.
Authors:
Gregory A Sacha; Wendy Saffell-Clemmer; Karen Abram; Michael J Akers
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  15     ISSN:  1097-9867     ISO Abbreviation:  Pharm Dev Technol     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6-34     Citation Subset:  IM    
Affiliation:
Research and Development, Baxter BioPharma Solutions, Bloomington, Indiana 47404, USA. gregory_sacha@baxter.com
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MeSH Terms
Descriptor/Qualifier:
Drug Packaging*
Glass*
Plastics*
Potassium Chloride / chemistry
Rubber*
Solubility
Chemical
Reg. No./Substance:
0/Plastics; 7447-40-7/Potassium Chloride; 9006-04-6/Rubber

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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