Document Detail

Practical experience of ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland.
MedLine Citation:
PMID:  21929536     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There are limited data on the use of ustekinumab outside of clinical trials.
OBJECTIVES: To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 dermatology centres in the U.K. and Ireland.
METHODS: A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab.
RESULTS: Baseline Psoriasis Area and Severity Index (PASI) was 22·9±10·1 (mean±SD). After 16weeks of treatment with ustekinumab PASI 75 (75% reduction in PASI) was observed in 63·0% (n=80/127) of patients, although four patients required concomitant therapy at the 16-week time point. Previous biologic use did show a small, non-significant trend towards treatment failure. A PASI 75 response was seen in 29·4% (n=5/17) of individuals weighing 90-100kg and treated with the standard 45mg ustekinumab dose compared with PASI 75 of 70·3%, 71·4%, 75·0% and 55·6% for weight groups <80, 80-90, 100-110 and >110kg, respectively (P=0·024). Ustekinumab therapy was well tolerated; serious adverse events were observed in 2·3% (n=3/129) of patients.
CONCLUSIONS: Ustekinumab is a novel biologic agent for psoriasis. When used in everyday clinical practice it demonstrates high levels of short-term therapeutic efficacy with an acceptable short-term safety profile.
P M Laws; A M Downs; R Parslew; B Dever; C H Smith; J N Barker; B Moriarty; R Murphy; B Kirby; A D Burden; S McBride; A V Anstey; S O'Shea; N Ralph; C Buckley; C E M Griffiths; R B Warren
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  166     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-03     Completed Date:  2012-03-16     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. BJD © 2011 British Association of Dermatologists.
Dermatological Sciences, Salford Royal Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, UK.
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MeSH Terms
Antibodies, Monoclonal / therapeutic use*
Biological Agents / therapeutic use*
Body Mass Index
Cost of Illness
Dermatologic Agents / therapeutic use*
Middle Aged
Psoriasis / drug therapy*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Biological Agents; 0/Dermatologic Agents; FU77B4U5Z0/ustekinumab

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