| Practical considerations of genetic rodent models for neurodegenerative diseases. | |
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MedLine Citation:
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PMID: 21913101 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In recent years, the rapid advances in human genetics have identified many genes that are responsible for inherited diseases. In the effort to understand pathogenic pathways and develop therapeutics, researchers have developed genetic animal models as critical tools for the purpose of neurodegenerative disease study. In this overview chapter, we do not intend to cover all the transgenic models for particular diseases, their phenotypical analyses, and their specific usage in this research field. Instead, we outline methods of genetic manipulation and their usage in disease modeling, explain the underlying principles of these methods, and compare the advantages and pitfalls to these different transgenic methods. |
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Authors:
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Kindiya Geghman; Chenjian Li |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 793 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 185-93 Citation Subset: IM |
Affiliation:
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Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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