Document Detail


Practical beta-lactone synthesis: epoxide carbonylation at 1 atm.
MedLine Citation:
PMID:  16898798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[reaction: see text] A readily prepared bimetallic catalyst is capable of effecting epoxide carbonylation to produce beta-lactones at substantially lower CO pressures than previously reported catalyst systems. A functionally diverse array of beta-lactones is produced in excellent yields at CO pressures as low as 1 atm. This procedure allows for epoxide carbonylation on a multigram scale without the requirement of specialized, high-pressure equipment.
Authors:
John W Kramer; Emil B Lobkovsky; Geoffrey W Coates
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Organic letters     Volume:  8     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2007-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3709-12     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA.
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MeSH Terms
Descriptor/Qualifier:
Catalysis
Chromium / chemistry
Crystallography, X-Ray
Epoxy Compounds / chemistry*
Ketones / chemical synthesis*,  chemistry
Lactones / chemical synthesis*,  chemistry
Molecular Conformation
Molecular Structure
Organometallic Compounds / chemistry
Stereoisomerism
Chemical
Reg. No./Substance:
0/Epoxy Compounds; 0/Ketones; 0/Lactones; 0/Organometallic Compounds; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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