Document Detail

Practical application of oxygen transport principles.
MedLine Citation:
PMID:  2403513     Owner:  NLM     Status:  MEDLINE    
Management of shock is generally guided by hemodynamic data, but the true aim of therapy should be optimizing oxygen delivery (DO2) and consumption (VO2). Available data do not support the hypothesis that there is a single critical threshold of DO2 below which tissue hypoxia occurs; thus, DO2 and VO2 should be addressed for each patient. Interventions that raise BP, such as infused catecholamines, may actually decrease DO2, as can mechanical ventilation with PEEP. Therefore, the clinician should avoid responding solely to hemodynamic data and should direct interventions toward delivering the optimum amount of oxygen to the patient's tissues.
J D Edwards
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care medicine     Volume:  18     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-06     Completed Date:  1990-02-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S45-8     Citation Subset:  AIM; IM    
Intensive Care Unit, University Hospital of South Manchester, UK.
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MeSH Terms
Hemoglobins / physiology
Lactates / blood
Oxygen / blood,  physiology*
Oxygen Consumption*
Shock / physiopathology*,  therapy
Shock, Cardiogenic / physiopathology
Shock, Septic / physiopathology
Shock, Traumatic / physiopathology
Reg. No./Substance:
0/Hemoglobins; 0/Lactates; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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