Document Detail


Practical synthesis of bredemolic Acid, a natural inhibitor of glycogen phosphorylase.
MedLine Citation:
PMID:  18847277     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Bredemolic acid (3) is a naturally occurring 2β,3α-isomer of maslinic acid (1) that is an allosteric site inhibitor of glycogen phosphorylase (GP). A practical synthesis of 3 was accomplished (18% yield) in five steps starting from the readily available 2β,3β-diol 6a. In a similar fashion, 2β,3α-dihydroxyurs-12-en-28-oic acid (4) was synthesized as a natural 2β,3α-isomer of corosolic acid (2). Compounds 3 and 4 exhibited significant inhibitory activity against rabbit muscle GPa with IC(50) values of 6.25 and 1.1 μM, respectively.
Authors:
Keguang Cheng; Pu Zhang; Jun Liu; Juan Xie; Hongbin Sun
Related Documents :
1457697 - Synthesis and ace inhibitory activity of the stereoisomers of perindopril (s 9490) and ...
22526277 - Radially asymmetric gastroesophageal acid reflux in the distal esophagus: examinations ...
22083127 - New perspectives on photosynthetic phosphorylation in the light of a torsional mechanis...
19719237 - Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency vir...
Publication Detail:
Type:  Journal Article     Date:  2008-10-11
Journal Detail:
Title:  Journal of natural products     Volume:  71     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2011-05-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1877-80     Citation Subset:  IM    
Affiliation:
Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, People's Republic of China, Jiangsu Center for Drug Screening, China Pharmaceutical University, 1 Shennonglu, Nanjing 210038, People's Republic of China, and Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires, CNRS UMR 8531, Ecole Normale Supérieure de Cachan, 61 Avenue du Pt Wilson, F-94235 Cachan, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Supramolecular control of a fast and reversible Diels-Alder reaction.
Next Document:  Tyrosine Derivatives Isolated from Streptomyces sp. IFM 10937 in a Screening Program for TRAIL-Resis...