Document Detail

Practical synthesis of bredemolic Acid, a natural inhibitor of glycogen phosphorylase.
MedLine Citation:
PMID:  18847277     Owner:  NLM     Status:  In-Data-Review    
Bredemolic acid (3) is a naturally occurring 2β,3α-isomer of maslinic acid (1) that is an allosteric site inhibitor of glycogen phosphorylase (GP). A practical synthesis of 3 was accomplished (18% yield) in five steps starting from the readily available 2β,3β-diol 6a. In a similar fashion, 2β,3α-dihydroxyurs-12-en-28-oic acid (4) was synthesized as a natural 2β,3α-isomer of corosolic acid (2). Compounds 3 and 4 exhibited significant inhibitory activity against rabbit muscle GPa with IC(50) values of 6.25 and 1.1 μM, respectively.
Keguang Cheng; Pu Zhang; Jun Liu; Juan Xie; Hongbin Sun
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Publication Detail:
Type:  Journal Article     Date:  2008-10-11
Journal Detail:
Title:  Journal of natural products     Volume:  71     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2011-05-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1877-80     Citation Subset:  IM    
Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, People's Republic of China, Jiangsu Center for Drug Screening, China Pharmaceutical University, 1 Shennonglu, Nanjing 210038, People's Republic of China, and Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires, CNRS UMR 8531, Ecole Normale Supérieure de Cachan, 61 Avenue du Pt Wilson, F-94235 Cachan, France.
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