| A practical approach to problems of hypercalcaemia. | |
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MedLine Citation:
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PMID: 19494663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypercalcaemia is a rarer problem in children than that of hypocalcaemia. However, when it does occur, it is a condition that requires proper diagnosis before correct treatment can be instituted. Problems may arise either because of excess PTH secretion, e.g. because of parathyroid tumour, or because of inactivating mutations of the calcium-sensing receptor or because some other factor, such as vitamin D or PTHrP, causes hypercalcaemia independently of PTH. In the latter instance, PTH secretion is suppressed. It is often useful to get a clue to the aetiology by examining the urine calcium concentration as this may guide one towards the correct diagnosis. Treatment is aimed at either removing the source of the excess PTH or whichever other factor is involved. In some cases treatment is not necessary as the hypercalcaemia remains asymptomatic and does not cause any problems. If the underlying problem cannot be treated directly, measures can often be taken to reduce the plasma calcium by medical means which can sometimes be used as an interim measure before definitive treatment is undertaken. |
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Authors:
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Justin H Davies |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-06-03 |
Journal Detail:
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Title: Endocrine development Volume: 16 ISSN: 1662-2979 ISO Abbreviation: Endocr Dev Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-04 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101138956 Medline TA: Endocr Dev Country: Switzerland |
Other Details:
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Languages: eng Pagination: 93-114 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Child Health, Southampton University Hospital Trust, Tremona Road, Southampton, UK. justin.davies@suht.swest.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcium
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metabolism Child Granuloma / etiology, therapy Homeostasis / physiology Humans Hypercalcemia / etiology, metabolism, physiopathology, therapy* Parathyroid Hormone / blood Receptors, Calcium-Sensing / genetics |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 0/Receptors, Calcium-Sensing; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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