Document Detail


Practicability and reliability of model of cerebral infarction in dog by microneurosurgical technique.
MedLine Citation:
PMID:  3796268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors used somatosensory evoked potentials (SEPs) and the electron microscope to evaluate the practicability and reliability of a model of cerebral infarction produced by microneurosurgery in the dog. Complete cerebral hemisphere infarction was produced by occluding various vessels from the circle of Willis. After occlusion, there was a precipitous decrease in the amplitude of cerebral cortical components (85.65 +/- 20.85 and 91.88 +/- 24.59 microV before compared to 4.08 +/- 1.99 and 2.85 +/- 1.38 microV after occlusion, P less than .001). The majority of the neurons at the 6th hour after occlusion became degenerated and contained no recognizable organelles. This study shows that the occlusion of various vessels from the base of the brain by microneurosurgery could produce a practical, reliable model of infarction with a high rate of success. The size and location of infarction can be controlled, and it is suitable for intracranial microvascular research.
Authors:
W G Jiang; S Q Li
Related Documents :
17311078 - Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct vol...
10449078 - Titration of postischemic cerebral hypoperfusion by variation of ischemic severity in a...
16463838 - The role of noninvasive monitoring of cerebral electrical impedance in stroke.
11108768 - Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induce...
25043578 - Dissociation of early shock in takotsubo cardiomyopathy from either right or left ventr...
1267908 - Myocardial protection during aortic valve replacement.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microsurgery     Volume:  7     ISSN:  0738-1085     ISO Abbreviation:  Microsurgery     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-17     Completed Date:  1987-02-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8309230     Medline TA:  Microsurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Infarction / etiology*
Circle of Willis / surgery
Disease Models, Animal
Dogs
Evoked Potentials, Somatosensory*
Microscopy, Electron
Microsurgery / methods
Neurosurgery / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Experimental study of regeneration of motor end plate.
Next Document:  Scanning electron microscopic study of microvascular anastomoses on irradiated vessels: long-term ef...