Document Detail

Practicability and reliability of model of cerebral infarction in dog by microneurosurgical technique.
MedLine Citation:
PMID:  3796268     Owner:  NLM     Status:  MEDLINE    
The authors used somatosensory evoked potentials (SEPs) and the electron microscope to evaluate the practicability and reliability of a model of cerebral infarction produced by microneurosurgery in the dog. Complete cerebral hemisphere infarction was produced by occluding various vessels from the circle of Willis. After occlusion, there was a precipitous decrease in the amplitude of cerebral cortical components (85.65 +/- 20.85 and 91.88 +/- 24.59 microV before compared to 4.08 +/- 1.99 and 2.85 +/- 1.38 microV after occlusion, P less than .001). The majority of the neurons at the 6th hour after occlusion became degenerated and contained no recognizable organelles. This study shows that the occlusion of various vessels from the base of the brain by microneurosurgery could produce a practical, reliable model of infarction with a high rate of success. The size and location of infarction can be controlled, and it is suitable for intracranial microvascular research.
W G Jiang; S Q Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microsurgery     Volume:  7     ISSN:  0738-1085     ISO Abbreviation:  Microsurgery     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-17     Completed Date:  1987-02-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8309230     Medline TA:  Microsurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
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MeSH Terms
Cerebral Infarction / etiology*
Circle of Willis / surgery
Disease Models, Animal
Evoked Potentials, Somatosensory*
Microscopy, Electron
Microsurgery / methods
Neurosurgery / methods

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