| Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome. | |
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MedLine Citation:
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PMID: 19073294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of the study was to evaluate quantitative sleep electroencephalogram (EEG) frequencies in monozygotic twins discordant for chronic fatigue syndrome. METHODS: Thirteen pairs of female twins underwent polysomnography. During the first night, they adapted to the sleep laboratory, and during the second night, their baseline sleep was assessed. Visual stage scoring was conducted on sleep electroencephalographic records according to standard criteria, and power spectral analysis was used to quantify delta through beta frequency bands, processed in 6-s blocks. Data were averaged across sleep stage within each twin and coded for sleep stage and the presence or absence of chronic fatigue syndrome (CFS). A completely within-subjects repeated measure multivariate analysis of variance evaluated twin pairs by frequency band by sleep stage interactions and simple effects. The relationship between alpha and delta EEG was also assessed across twin pairs. RESULTS: No significant differences in spectral power in any frequency band were found between those with CFS and their nonfatigued cotwins. Phasic alpha activity, coupled with delta was noted in five subjects with CFS but was also present in 4/5 healthy twins, indicating this finding likely reflects genetic influences on the sleep electroencephalogram rather than disease-specific sleep pathology. CONCLUSIONS: The genetic influences on sleep polysomnography and microarchitecture appear to be stronger than the disease influence of chronic fatigue syndrome, despite greater subjective sleep complaint among the CFS twins. EEG techniques that focus on short duration events or paradigms that probe sleep regulation may provide a better description of sleep abnormalities in CFS. |
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Authors:
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Roseanne Armitage; Carol Landis; Robert Hoffmann; Martha Lentz; Nathaniel Watson; Jack Goldberg; Dedra Buchwald |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Twin Study Date: 2008-11-25 |
Journal Detail:
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Title: Journal of psychosomatic research Volume: 66 ISSN: 0022-3999 ISO Abbreviation: J Psychosom Res Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-03-23 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 0376333 Medline TA: J Psychosom Res Country: England |
Other Details:
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Languages: eng Pagination: 51-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. rosearmi@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alpha Rhythm Delta Rhythm Diseases in Twins / genetics*, psychology Electroencephalography* Fatigue Syndrome, Chronic / diagnosis, genetics* Female Fourier Analysis Humans Middle Aged Polysomnography Signal Processing, Computer-Assisted* Sleep Stages / genetics Twins, Monozygotic / genetics, psychology |
| Grant Support | |
ID/Acronym/Agency:
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NR04011/NR/NINR NIH HHS; U19 AI038429-07/AI/NIAID NIH HHS; U19AI38429/AI/NIAID NIH HHS |
| Comments/Corrections | |
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