Document Detail


Power spectral analysis of heart rate variability for assessment of diurnal variation of autonomic nervous activity in miniature swine.
MedLine Citation:
PMID:  10331551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSES: The purpose of the study was to document diurnal variation of autonomic nervous functions by use of power spectral analysis of heart rate (HR) variability. METHODS: To clarify characteristics of power spectral analysis of HR variability, electrocardiogram (ECG), blood pressure (BP), and respiratory (Resp) waveform simultaneously were recorded. RESULTS: Two major spectral components were examined at low (LF)- and high (HF)-frequency bands for HR variability. Coherence between HR and Resp variabilities and HR and BP variabilities was maximal at approximately 0.14 and 0.03 Hz, respectively. On the basis of these data, two frequency bands of interest--LF (0.01 to 0.07 Hz) and HF (0.07 to 1.0 Hz)--were defined. Autonomic blockade studies indicated that the parasympathetic system mediated the HF and LF components, whereas the sympathetic system mediated only the LF component; HR had a diurnal pattern. The LF and HF bands in the dark phase tended to be higher than those in the light phase. The LF-to-HF ratio had a diurnal pattern similar to that of the HR. CONCLUSION: Parasympathetic nervous activity in miniature swine may be predominant in the dark phase. The characteristics of power spectra and diurnal variations of autonomic nervous functions are almost the same as those of humans. Therefore, miniature swine may be a useful animal model for future biobehavioral and pharmacotoxicologic studies.
Authors:
M Kuwahara; A Suzuki; H Tsutsumi; M Tanigawa; H Tsubone; S Sugano
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Laboratory animal science     Volume:  49     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  202-8     Citation Subset:  IM    
Affiliation:
Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Autonomic Nervous System / drug effects,  physiology*
Circadian Rhythm*
Electrocardiography*
Heart Rate*
Male
Parasympatholytics / pharmacology
Propranolol / pharmacology
Swine
Swine, Miniature / physiology*
Sympatholytics / pharmacology
Chemical
Reg. No./Substance:
0/Parasympatholytics; 0/Sympatholytics; 51-55-8/Atropine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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