| Power-law dynamics in an auditory-nerve model can account for neural adaptation to sound-level statistics. | |
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MedLine Citation:
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PMID: 20685981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurons in the auditory system respond to recent stimulus-level history by adapting their response functions according to the statistics of the stimulus, partially alleviating the so-called "dynamic-range problem." However, the mechanism and source of this adaptation along the auditory pathway remain unknown. Inclusion of power-law dynamics in a phenomenological model of the inner hair cell (IHC)-auditory nerve (AN) synapse successfully explained neural adaptation to sound-level statistics, including the time course of adaptation of the mean firing rate and changes in the dynamic range observed in AN responses. A direct comparison between model responses to a dynamic stimulus and to an "inversely gated" static background suggested that AN dynamic-range adaptation largely results from the adaptation produced by the response history. These results support the hypothesis that the potential mechanism underlying the dynamic-range adaptation observed at the level of the auditory nerve is located peripheral to the spike generation mechanism and central to the IHC receptor potential. |
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Authors:
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Muhammad S A Zilany; Laurel H Carney |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-08-24 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 10380-90 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA. msazilany@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Auditory Pathways
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physiology* Auditory Perception / physiology* Auditory Threshold / physiology Cochlear Nerve / physiology* Computer Simulation Models, Neurological Sound |
| Grant Support | |
ID/Acronym/Agency:
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R01 DC001641-13/DC/NIDCD NIH HHS; R01 DC001641-21/DC/NIDCD NIH HHS; R01-DC01641/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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