| Power Fluctuations in Beta and Gamma Frequencies in Rat Globus Pallidus: Association with Specific Phases of Slow Oscillations and Differential Modulation by Dopamine D1 and D2 Receptors. | |
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MedLine Citation:
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PMID: 21508235 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Modulation of oscillatory activity through basal ganglia-cortical loops in specific frequency bands is thought to reflect specific functional states of neural networks. A specific negative correlation between beta and gamma sub-bands has been demonstrated in human basal ganglia and may be key for normal basal ganglia function. However, these studies were limited to Parkinson's disease patients. To confirm that this interaction is a feature of normal basal ganglia, we recorded local field potential (LFP) from electrodes in globus pallidus (GP) of intact rats. We found significant negative correlation between specific frequencies within gamma (≈60 Hz) and beta (≈14 Hz) bands. Furthermore, we show that fluctuations in power at these frequencies are differentially nested within slow (≈3 Hz) oscillations in the delta band, showing maximum power at distinct and different phases of delta. These results suggest a hierarchical organization of LFP frequencies in the rat GP, in which a low-frequency signal in the basal ganglia can predict the timing and interaction of power fluctuations across higher frequencies. Finally, we found that dopamine D(1) and D(2) receptor antagonists differentially affected power in gamma and beta bands and also had different effects on correlation between them and the nesting within delta, indicating an important role for endogenous dopamine acting on direct and indirect pathway neurons in the maintenance of the hierarchical organization of frequency bands. Disruption of this hierarchical organization and subsequent disordered beta-gamma balance in basal ganglia disorders such as Parkinson's disease may be important in the pathogenesis of their symptoms. |
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Authors:
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Cyril Dejean; Gordon Arbuthnott; Jeffery R Wickens; Catherine Le Moine; Thomas Boraud; Brian I Hyland |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: 6098-6107 Citation Subset: - |
Affiliation:
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Departments of Anatomy and Structural Biology and Physiology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand, Okinawa Institute for Science and Technology, Okinawa, Japan 904-0412, Université de Bordeaux 1, Institut des Neurosciences Cognitives et Intégratives d'Aquitaine, Centre National de la Recherche Scientifique, (CNRS) Unité Mixte de Recherche (UMR) 5287, F-33000 Bordeaux, France, Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France, and CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France. |
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