Document Detail

Power Doppler ultrasonography assessment of entheses in spondyloarthropathies: response to therapy of entheseal abnormalities.
MedLine Citation:
PMID:  20810495     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To investigate the response to therapy of entheseal abnormalities assessed with power Doppler (PD) ultrasound (US) in spondyloarthropathies (SpA).
METHODS: A total of 327 patients with active SpA who were starting anti-tumor necrosis factor (TNF) therapy were prospectively recruited at 35 Spanish centers. A PDUS examination of 14 peripheral entheses was performed by the same investigator in each center at baseline and at 6 months. The following elementary lesions were assessed at each enthesis (presence/absence): morphologic abnormalities (hypoechogenicity and/or thickening), entheseal calcific deposits, cortical abnormalities (bone erosion and/or proliferation), adjacent bursitis and intraenthesis and perienthesis (tendon body and/or bursa) PD signal. Response to therapy of each elementary lesion was assessed by calculating change in the cumulative presence from baseline to 6 months. Intraobserver reliability of PDUS was evaluated by blindly assessing the stored baseline images 3 months after the real-time examination.
RESULTS: Complete data were obtained on 197 patients who received anti-TNF therapy for 6 months. In 91.4% of the patients there were gray-scale or PD elementary lesions at baseline and at 6 months. Cumulative entheseal morphologic abnormalities, intraenthesis PD, perienthesis PD, and bursitis showed a significant decrease from baseline to 6 months (p < 0.05). There was high intraobserver reliability for all elementary lesions (interclass correlation coefficient > 0.90, p < 0.0005).
CONCLUSION: Entheseal morphologic abnormalities, PD signal, and bursitis were US abnormalities that were responsive to anti-TNF therapy in SpA. PDUS can be a reproducible method for multicenter monitoring of therapeutic response in enthesitis of SpA.
Esperanza Naredo; Enrique Batlle-Gualda; M Luz García-Vivar; Angel M García-Aparicio; Jose Luis Fernández-Sueiro; Manuel Fernández-Prada; Emilio Giner; Manuel Rodriguez-Gomez; Maria Francisca Pina; Julio A Medina-Luezas; Francisco Javier Toyos; Cristina Campos; Ricardo Gutiérrez-Polo; Miguel Angel Ferrer; Olga Martínez; Cesar Díaz-Torne; Teresa Gonzalez; Serafín Campos; Rubén Queiro; Manuel Castaño-Sánchez; Juan José Aznar; Sagrario Bustabad; Manuel Paez-Camino; Roser Tuneu; Teresa Ruiz; Lourdes Mateo; Manuel Pujol; Andrés Ponce; Inmaculada Ros; Angel Gallegos; Juan Moreno; Domingo Gumbau; Manuela Sianes; M Jose Poveda-Elices; Montserrat Romero-Gómez; Enrique Raya;
Related Documents :
10599365 - Sulphasalazine. an alternative drug for second-line treatment of juvenile chronic arthr...
21224435 - Early jejunal feeding initiation and clinical outcomes in patients with severe acute pa...
24228695 - Off-clamp versus complete hilar control partial nephrectomy for renal cell carcinoma: a...
23778445 - Improving overtriage of aeromedical transport in trauma: a regional process improvement...
16798215 - Patient and surgical factors influencing air leak after lung volume reduction surgery: ...
12232885 - Compliance with recommendations of the urodynamic society for standards of efficacy for...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-01
Journal Detail:
Title:  The Journal of rheumatology     Volume:  37     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  2110-7     Citation Subset:  IM    
Department of Rheumatology, Hospital Universitario Severo Ochoa, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Comment In:
J Rheumatol. 2010 Oct;37(10):1986-8   [PMID:  20889609 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Growing trend of China's contribution to the field of rheumatology 2000-2009: a survey of Chinese rh...
Next Document:  Clinical manifestations but not cytokine profiles differentiate adult-onset Still's disease and seps...