Document Detail

Povidone-iodine-induced burn: case report and review of the literature.
MedLine Citation:
PMID:  17064209     Owner:  NLM     Status:  MEDLINE    
Burns are a rare but potentially serious complication of povidone-iodine use. This rare adverse drug reaction developed in a 38-year-old woman who underwent laparoscopic right ovarian cystectomy and endometrial ablation as a day procedure involving application of the topical antiseptic 10% povidone-iodine solution. Two days later, the patient was admitted to the hospital with burning, pain, itching, marked redness, and blistering extending from her midback to buttocks. A stain on her back also was evident. Partial-thickness chemical burn was diagnosed. Review of the literature yielded 13 other cases of povidone-iodine-induced burn. This underrecognized adverse effect of povidone-iodine application typically occurs when the povidone-iodine has not been allowed to dry or has been trapped under the body of a patient in a pooled dependent position. The burn is usually seen immediately after the procedure or on the next day, and typically heals with minimum scarring within 3-4 weeks with conservative treatment. The commonly postulated mechanism is a chemical burn due to irritation coupled with maceration, friction, and pressure. Given the widespread use of povidone-iodine and the potential for development of infection after a burn, clinicians need to be aware of this possible povidone-iodine-associated adverse drug reaction, and of preventive measures.
Donna O Lowe; Sandra R Knowles; Elizabeth A Weber; Craig J Railton; Neil H Shear
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  26     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-26     Completed Date:  2007-01-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1641-5     Citation Subset:  IM    
Department of Pharmacy Services, Toronto General Hospital, University Health Network, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Anti-Infective Agents, Local / adverse effects*
Bacitracin / therapeutic use
Burns, Chemical / etiology*
Polymyxin B / therapeutic use
Povidone-Iodine / adverse effects*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents, Local; 118933-13-4/bacitracin, polymyxin B drug combination; 1404-26-8/Polymyxin B; 1405-87-4/Bacitracin; 25655-41-8/Povidone-Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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