Document Detail

Potentiation of vasoconstrictor response and inhibition of endothelium-dependent vasorelaxation by gallic acid in rat aorta.
MedLine Citation:
PMID:  12221589     Owner:  NLM     Status:  MEDLINE    
In the isolated rat thoracic aorta, gallic acid potentiated the vasoconstrictor response to phenylephrine. The potentiation produced by gallic acid was absent in endothelium-denuded arteries. The potentiation was abolished by N(G)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis, and slightly attenuated by an addition of L-arginine, while indomethacin or BQ610 had no effect. The potentiation of response to phenylephrine was not found for structural modifications of gallic acid, except for caffeic acid. Gallic acid also inhibited vasorelaxation induced by acetylcholine, sodium nitroprusside or prostacyclin, especially that by acetylcholine. The effect on vasorelaxation induced by acetylcholine was decreased by esterification of the carboxy group of gallic acid, and in the absence or by the methylation of the o-dihydroxy group. Caffeic acid inhibited the vasorelaxation, though the effect was smaller than that of gallic acid. These findings indicate that gallic acid produces a potentiation of contractile response and inhibition of vasorelaxant responses, probably through inactivation of nitric oxide (NO), in which endothelially produced NO is principally involved, and that the modification of functional groups of the gallic acid molecule abolishes the potentiation of contractile response and attenuates the inhibition of vasorelaxant responses.
Fujiko Sanae; Yukinori Miyaichi; Hisao Hayashi
Related Documents :
16659699 - Changes in anthocyanin and phenolics content of grapevine leaf and fruit tissues treate...
15678719 - Quality evaluation of honey harvested from selected areas in tanzania with special emph...
17848079 - Identification of flavonoids and hydroxycinnamic acids in pak choi varieties (brassica ...
21056309 - Analysis of caffeic acid extraction from ocimum gratissimum linn. by high performance l...
18608569 - Release of antioxidant components from tomatoes determined by an in vitro digestion met...
17726749 - Effect of chlorogenic acid on antioxidant activity of flos lonicerae extracts.
6138349 - Vitamin k-dependent carboxylase. demonstration of a vitamin k- and o2-dependent exchang...
7770779 - Chemical characterization of a family of brain lipids that induce sleep.
5651209 - Acetylation of human serum albumin by acetylsalicylic acid.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  68     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-10     Completed Date:  2002-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  690-3     Citation Subset:  IM    
Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcholine / pharmacology
Aorta, Thoracic / drug effects*
Caffeic Acids / pharmacology
Endothelium, Vascular / drug effects
Gallic Acid / analogs & derivatives,  pharmacology*
Isometric Contraction / drug effects
Logistic Models
Molecular Structure
Phenylephrine / pharmacology
Plants, Medicinal / chemistry
Rats, Wistar
Structure-Activity Relationship
Vasoconstriction / drug effects*
Vasoconstrictor Agents / pharmacology*
Vasodilation / drug effects*
Reg. No./Substance:
0/Caffeic Acids; 0/Vasoconstrictor Agents; 149-91-7/Gallic Acid; 331-39-5/caffeic acid; 51-84-3/Acetylcholine; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of inducible nitric oxide synthesis by catalposide from Catalpa ovata.
Next Document:  Involvement of nitric oxide in the mediation of the hypotensive action of the essential oil of Menth...