Document Detail

Potentiation of omega-3 fatty acid antidepressant-like effects with low non-antidepressant doses of fluoxetine and mirtazapine.
MedLine Citation:
PMID:  20826148     Owner:  NLM     Status:  MEDLINE    
Despite the advances in psychopharmacology, the treatment of depressive disorders is still not satisfactory. Side effects and resistance to antidepressant drugs are the greatest complications during treatment. Based on recent evidence, omega-3 fatty acids may influence vulnerability and outcome in depressive disorders. The aim of this study was to further characterize the omega-3 antidepressant-like effect in rats in terms of its behavioral features in the depression model forced swimming test either alone or in combination with antidepressants fluoxetine or mirtazapine. Ultimately, we prompted to determine the lowest dose at which omega-3 fatty acids and antidepressant drugs may still represent a pharmacological advantage when employed in combined treatments. Chronic diet supplementation with omega-3 fatty acids produced concentration-dependent antidepressant-like effects in the forced swimming test displaying a behavioral profile similar to fluoxetine but different from mirtazapine. Fluoxetine or mirtazapine at antidepressant doses (10 and 20 mg/kg/day, respectively) rendered additive effects in combination with omega-3 fatty acid supplementation (720 mg/kg/day). Beneficial effects of combined treatment were also observed at sub-effective doses (1 mg/kg/day) of fluoxetine or mirtazapine, since in combination with omega-3 fatty acids (720 mg/kg/day), antidepressants potentiated omega-3 antidepressant-like effects. The antidepressant-like effects occurred in the absence of changes in brain phospholipid classes. The therapeutic approach of combining omega-3 fatty acids with low ineffective doses of antidepressants might represent benefits in the treatment of depression, especially in patients with depression resistant to conventional treatments and even may contribute to patient compliance by decreasing the magnitude of some antidepressant dose-dependent side effects.
Carlos Horacio Laino; Cristina Fonseca; Norma Sterin-Speziale; Nora Slobodianik; Analía Reinés
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-15
Journal Detail:
Title:  European journal of pharmacology     Volume:  648     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-26     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Instituto de Investigaciones en Ciencias de la Salud Humana (IICSHUM), Departamento de Ciencias Exactas, Fisicas y Naturales, Universidad Nacional de La Rioja, Argentina.
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MeSH Terms
Antidepressive Agents / pharmacology*
Behavior, Animal / drug effects
Body Weight / drug effects
Dose-Response Relationship, Drug
Drug Synergism
Fatty Acids, Omega-3 / pharmacology*
Fluoxetine / pharmacology*
Mianserin / analogs & derivatives*,  pharmacology
Rats, Wistar
Time Factors
Reg. No./Substance:
0/Antidepressive Agents; 0/Fatty Acids, Omega-3; 24219-97-4/Mianserin; 54910-89-3/Fluoxetine; 61337-67-5/mirtazapine

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