Document Detail

Potentiation of morphine analgesia by subanesthetic doses of pentobarbital.
MedLine Citation:
PMID:  3991755     Owner:  NLM     Status:  MEDLINE    
Pentobarbital pretreatment reportedly either inhibits, enhances or has no effect on morphine analgesia. The effect of subanesthetic doses of sodium pentobarbital (8-12 mg kg-1, SC) delivered via a delivery system on analgesia of morphine (5 mg kg-1, SC or 1 mg kg-1, IV) acutely administered 45 min after the sodium pentobarbital pellet implantation was assessed using the warm water (55 degrees C)-induced tail-withdrawal reflex in male Wistar rats. Significant potentiation of morphine analgesia was observed in sodium pentobarbital as compared to the placebo-pelleted animals. Pharmacokinetic or dispositional factors were not involved in this potentiation, which was possibly due to the activation of the descending inhibitory control pathways of nociceptive spinal tail-withdrawal reflex by a combined interaction of two drugs at spinal and supraspinal sites of action, that mediate opiate antinociception.
R B Pontani; N L Vadlamani; A L Misra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  22     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-29     Completed Date:  1985-05-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
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MeSH Terms
Drug Compounding
Drug Implants
Drug Synergism
Morphine / pharmacology*
Nociceptors / drug effects
Pentobarbital / pharmacology*
Rats, Inbred Strains
Reaction Time / drug effects
Time Factors
Reg. No./Substance:
0/Analgesics; 0/Drug Implants; 0/Triglycerides; 555-43-1/tristearin; 57-27-2/Morphine; 57-88-5/Cholesterol; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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