Document Detail

Potentiation of mitogenesis in adult rat chromaffin cell cultures by immunosuppressive agent FK506.
MedLine Citation:
PMID:  14746888     Owner:  NLM     Status:  MEDLINE    
The immunosuppressive drugs FK506 and cyclosporin inhibit T- and B-lymphocyte proliferation and exert neuritogenic and/or cytoprotective effects on several types of neurons. While the immunosuppressive actions of both drugs are mediated in large part by inhibition of the Ca(2+)-dependent phosphatase, calcineurin, FK506 is known to exert additional effects. In the present study, FK506 is shown to potentiate mitogenic effects of the neurotrophic factor, neurturin, on normal adult rat adrenal chromaffin cells in culture. The effect is not seen with cyclosporin or with a non-immunosuppressive analog of FK506, GPI-1046. The finding of increased mitogenesis in response to FK506 may have applications to the study of normal and neoplastic neuroendocrine cells and to understanding the development of some types of tumors in transplant patients.
J F Powers; J M Brachold; K Schelling; A S Tischler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  356     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-28     Completed Date:  2004-03-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
Department of Pathology, Tufts New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA.
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MeSH Terms
Adjuvants, Immunologic / pharmacology*
Cell Culture Techniques
Chromaffin Cells / cytology*,  drug effects*
Immunosuppressive Agents / pharmacology*
Mitogens / pharmacology*
Mitosis / drug effects*,  physiology
Rats, Inbred F344
Grant Support
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Immunosuppressive Agents; 0/Mitogens

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