| Potentiation of melphalan by systemic hyperthermia in mice: therapeutic gain for mouse lung microtumours. | |
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MedLine Citation:
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PMID: 3837082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of systemic hyperthermia at 41 degrees C on the response to melphalan (Mel) of KHT and RIF-1 lung microtumours was studied. Mice with KHT microtumours were treated on day 3 or 4 after inoculation and mice with RIF-1 microtumours on day 4. Results were compared with previously published data for 300-600 mm3 leg tumours and normal marrow stem cells, and therapeutic ratios (TR) were calculated. Therapeutic gain was found for both tumours but in RIF-1 at higher doses only, with TRs from 1.1 to 1.6 for KHT microtumours and from 0.8 to 1.4 for RIF-1. TR values were rather smaller for lung microtumours than leg tumours but the change in slope of the Mel dose response curve by heat was very similar. The results are discussed in the light of the likely difference of tumour milieu between leg tumours and lung microtumours. |
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Authors:
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D J Honess; N M Bleehen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group Volume: 1 ISSN: 0265-6736 ISO Abbreviation: Int J Hyperthermia Publication Date: 1985 Jan-Mar |
Date Detail:
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Created Date: 1986-09-16 Completed Date: 1986-09-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8508395 Medline TA: Int J Hyperthermia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 57-68 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Combined Modality Therapy Female Fibrosarcoma / therapy Hyperthermia, Induced* Lung Neoplasms / drug therapy, pathology, therapy* Melphalan / therapeutic use* Mice Mice, Inbred C3H Sarcoma, Experimental / therapy Tumor Stem Cell Assay |
| Chemical | |
Reg. No./Substance:
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148-82-3/Melphalan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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