Document Detail

Potentiation of melphalan by systemic hyperthermia in mice: therapeutic gain for mouse lung microtumours.
MedLine Citation:
PMID:  3837082     Owner:  NLM     Status:  MEDLINE    
The effect of systemic hyperthermia at 41 degrees C on the response to melphalan (Mel) of KHT and RIF-1 lung microtumours was studied. Mice with KHT microtumours were treated on day 3 or 4 after inoculation and mice with RIF-1 microtumours on day 4. Results were compared with previously published data for 300-600 mm3 leg tumours and normal marrow stem cells, and therapeutic ratios (TR) were calculated. Therapeutic gain was found for both tumours but in RIF-1 at higher doses only, with TRs from 1.1 to 1.6 for KHT microtumours and from 0.8 to 1.4 for RIF-1. TR values were rather smaller for lung microtumours than leg tumours but the change in slope of the Mel dose response curve by heat was very similar. The results are discussed in the light of the likely difference of tumour milieu between leg tumours and lung microtumours.
D J Honess; N M Bleehen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group     Volume:  1     ISSN:  0265-6736     ISO Abbreviation:  Int J Hyperthermia     Publication Date:    1985 Jan-Mar
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8508395     Medline TA:  Int J Hyperthermia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  57-68     Citation Subset:  IM    
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MeSH Terms
Combined Modality Therapy
Fibrosarcoma / therapy
Hyperthermia, Induced*
Lung Neoplasms / drug therapy,  pathology,  therapy*
Melphalan / therapeutic use*
Mice, Inbred C3H
Sarcoma, Experimental / therapy
Tumor Stem Cell Assay
Reg. No./Substance:

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