Document Detail

Potentiation of magnesium-induced neuromuscular weakness by gentamicin.
MedLine Citation:
PMID:  6848309     Owner:  NLM     Status:  MEDLINE    
A term neonate with hypermagnesemia secondary to maternal administration of MgSO4 for pre-eclampsia had a respiratory arrest after receiving gentamicin im. The neuromuscular tracings and sequential physician exams done before and after administering gentamicin suggest aminoglycosides may potentiate a magnesium-induced impairment of neuromuscular transmission and cause muscular weakness in neonates.
C S L'Hommedieu; P A Huber; D K Rasch
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  11     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-6     Citation Subset:  AIM; IM    
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MeSH Terms
Critical Care
Drug Synergism
Gentamicins / adverse effects*
Infant, Newborn
Magnesium / adverse effects*
Neuromuscular Diseases / chemically induced*
Reg. No./Substance:
0/Gentamicins; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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