Document Detail

Potentiation of itch and flare responses in human skin by prostaglandins E2 and H2 and a prostaglandin endoperoxide analog.
MedLine Citation:
PMID:  925375     Owner:  NLM     Status:  MEDLINE    
The itch and erythematous responses induced by intradermal injection of prostaglandin E2 (PGE2), the unstable prostaglandin endoperoxide PGH2 (t1/2 approximately 5 min at 37 degrees C) and the stable endoperoxide analog (15S)-hydroxy-9alpha, 11alpha-(epoxymethano)prosta-5,13-dienoic acid (EPA) were studied in volunteers. The compounds were given alone or in combination with histamine. All the compounds produced flare reaction in the skin; the order of potency was PGE2 greater than PGH2 greater than EPA. PGE2 and PGH2 evoked a sensation of itch in about half of the subjects whereas the same doses of EPA gave no itch response. In combination with histamine all compounds elicited itch of longer duration and flare of larger area than could be accounted for by simple additive effects of any released histamine. The results indicate that the PGs and PG intermediates formed in skin may potentiate the pruritogenic and flare-inducing effects of inflammagens in man.
O Hägermark; K Strandberg; M Hamberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  69     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-30     Citation Subset:  AIM; IM    
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MeSH Terms
Drug Synergism
Histamine / pharmacology
Inflammation / chemically induced*
Prostaglandin Endoperoxides / pharmacology*
Prostaglandin Endoperoxides, Synthetic / pharmacology*
Prostaglandins E / pharmacology*
Prostaglandins H / pharmacology*
Pruritus / chemically induced*
Skin / drug effects
Reg. No./Substance:
0/Prostaglandin Endoperoxides; 0/Prostaglandin Endoperoxides, Synthetic; 0/Prostaglandins E; 0/Prostaglandins H; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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