Document Detail

Potentiation of dipsogenic actions by centrally administered type-C natriuretic peptide in spontaneously hypertensive but not Wistar-Kyoto rats.
MedLine Citation:
PMID:  9406658     Owner:  NLM     Status:  MEDLINE    
1. The effects of type-C natriuretic polypeptides (CNP) on the central dipsogenic and pressor responses to angiotensin II (AngII) were studied by the administration of agents into the lateral cerebral ventricle under conscious and unrestrained conditions in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. The fluid intake induced by AngII (25 ng) and water deprivation were potentiated after pretreatment with CNP in SHR but not in WKY rats. However, carbachol-induced water intake was not altered by pretreatment with CNP (2.5 micrograms) in either WKY rats or SHR. 3. In contrast, CNP did not influence the pressor responses to AngII in either WKY rats or SHR.
E Goto; K Shibata; T Furukawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  24     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-01-12     Completed Date:  1998-01-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  927-34     Citation Subset:  IM    
Emergency and Critical Care Medicine, Fukuoka University Hospital, Japan.
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MeSH Terms
Angiotensin II / pharmacology
Blood Pressure / drug effects,  physiology*
Carbachol / pharmacology
Cardiovascular System / drug effects
Drinking / drug effects*,  physiology
Drug Synergism
Injections, Intraventricular
Natriuretic Peptide, C-Type
Proteins / pharmacology*
Rats, Inbred SHR
Rats, Inbred WKY
Thirst / drug effects,  physiology
Water Deprivation / physiology
Reg. No./Substance:
0/Proteins; 11128-99-7/Angiotensin II; 127869-51-6/Natriuretic Peptide, C-Type; 51-83-2/Carbachol

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