Document Detail

Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF.
MedLine Citation:
PMID:  8497318     Owner:  NLM     Status:  MEDLINE    
The neurotrophins are a family of neurotrophic factors that promote survival and differentiation of various neuronal populations. Although the long-term effects of neurotrophins on neuronal survival and differentiation have been intensively studied, nothing is known about their effects on synaptic function. Here we report that acute exposure to neurotrophin-3 (NT-3) or brain-derived neurotrophic factor (BDNF), but not nerve growth factor (NGF), rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture. The effect appears to be presynaptic in origin and to be mediated by the Trk family of receptor tyrosine kinases. These results provide evidence for the regulation of the function of developing synapses by neurotrophins.
A M Lohof; N Y Ip; M M Poo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  363     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-24     Completed Date:  1993-06-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  350-3     Citation Subset:  IM    
Department of Biological Sciences, Columbia University, New York, New York 10027.
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MeSH Terms
Brain-Derived Neurotrophic Factor
Carbazoles / pharmacology
Culture Techniques
Indole Alkaloids
Nerve Growth Factors / physiology*
Nerve Tissue Proteins / physiology*
Neuromuscular Junction / physiology
Neurotrophin 3
Protein-Tyrosine Kinases / metabolism
Synapses / drug effects,  physiology*
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Carbazoles; 0/Indole Alkaloids; 0/Nerve Growth Factors; 0/Nerve Tissue Proteins; 0/Neurotrophin 3; 97161-97-2/K 252; EC Kinases

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