| Potentiation by gentamicin of non-depolarizing neuromuscular block in the cat. | |
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MedLine Citation:
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PMID: 7386847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gentamicin 1-5 mg/kg was injected into 14 anaesthetised cats in the presence of a constant, partial, non-depolarizing neuromuscular block. Twitch response in tibialis anterior was significantly depressed from 83% to 71% of control by a dose of 1.0 mg/kg. In soleus the same dose reduced twitch response from 76% to 71%. After a cumulative dose of 10 mg/kg twitch response in tibialis anterior and soleus was 34% and 37% of control respectively. Calcium chloride 20 mg/kg restored twitch response to 66% in both muscles. Smaller doses of calcium chloride caused partial reversal which was maintained for five minutes in only 50% of instances. |
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Authors:
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J M Potter; R O Edeson; R J Campbell; A M Forbes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 8 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 1980 Feb |
Date Detail:
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Created Date: 1980-08-15 Completed Date: 1980-08-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 20-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Chloride / administration & dosage Cats Gentamicins / administration & dosage* Muscle Relaxants, Central / pharmacology Neuromuscular Blocking Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins; 0/Muscle Relaxants, Central; 0/Neuromuscular Blocking Agents; 10043-52-4/Calcium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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