Document Detail


Potentiation by carbon tetrachloride of the immunosuppressive effects of fibrosarcoma and toxic material produced by fibrosarcoma cells.
MedLine Citation:
PMID:  1206736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SaD2-AG fibrosarcomas growing in DBA/2 mice caused nonspecific immunodepression. Injection of soluble material produced by cultured SaD2-AG cells into normal DBA/2 recipients caused nonspecific immunodepression and signs of systemic toxicity. These in vivo effects were enhanced by prior treatment of the recipients with carbon tetrachloride (CCl4). In contrast, material released by syngeneic fibroblasts was neither immunosuppressive nor toxic to normal mice or mice previously treated with CCl4. A soluble toxic material released by the fibrosarcoma cells may be responsible for at least some of the systemic effects of localized SaD2-AG tumors growing at a site not involving vital structures, and a protective host mechanism whose maximum capacity can be decreased by the administration of CCl4 may minimize the toxic effects of the cancer-derived material.
Authors:
A O Wong; R Mankovitz; J C Kennedy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  55     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-15     Completed Date:  1976-03-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1113-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects
Carbon Tetrachloride / pharmacology*
Cells, Cultured
Dose-Response Relationship, Drug
Fibrosarcoma / immunology*,  metabolism
Immune Adherence Reaction
Liver / drug effects
Mice
Mice, Inbred DBA
Motor Activity / drug effects
Sarcoma, Experimental / immunology
Toxins, Biological / biosynthesis
Chemical
Reg. No./Substance:
0/Toxins, Biological; 56-23-5/Carbon Tetrachloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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