Document Detail

Potentiation of arsenic neurotoxicity by folate deprivation: protective role of S-adenosyl methionine.
MedLine Citation:
PMID:  18284027     Owner:  NLM     Status:  MEDLINE    
Folate deficiency contributes to a variety of age-related neurological and psychological disorders including amyotrophic lateral sclerosis (ALS). The environmental neurotoxin arsenic has recently been linked with decreased neurofilament (NF) content in peripheral nerve. We examined herein, whether or not folate deprivation potentiated the impact of arsenic on NF dynamics. Arsenic inhibited translocation of NFs into axonal neurites in culture and increased perikaryal NF phosphoepitopes. Folate deprivation potentiated the impact of arsenic on these phenomena. Supplementation with S-adenosyl methionine (SAM) attenuated the impact of folate deprivation on arsenic neurotoxicity, consistent with the decrease in SAM following folate deprivation and the requirement for SAM-mediated methylation for arsenic bioelimination. These findings demonstrate how key nutritional deficiencies can potentiate the impact of enrivonmental neurotoxins.
Maya Dubey; Thomas B Shea
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  10     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:    2007 Oct-Dec
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Department of Biological Sciences, Center for Cellular Neurobiology and Neurodegeneration Research, University of Massachusetts, Lowell, MA 01854, USA.
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MeSH Terms
Amyotrophic Lateral Sclerosis / chemically induced
Arsenic / toxicity*
Axons / ultrastructure
Bucladesine / pharmacology
Cell Line
Cytoskeleton / drug effects
Folic Acid / administration & dosage*,  physiology
Green Fluorescent Proteins / genetics
Nervous System Diseases / chemically induced*,  prevention & control
Neurites / physiology,  ultrastructure
Neurofilament Proteins / analysis,  genetics,  metabolism
Recombinant Fusion Proteins
S-Adenosylmethionine / administration & dosage*
Reg. No./Substance:
0/Neurofilament Proteins; 0/Recombinant Fusion Proteins; 111365-29-8/neurofilament protein M; 147336-22-9/Green Fluorescent Proteins; 29908-03-0/S-Adenosylmethionine; 362-74-3/Bucladesine; 59-30-3/Folic Acid; 7440-38-2/Arsenic

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