| Potentiation of arsenic neurotoxicity by folate deprivation: protective role of S-adenosyl methionine. | |
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MedLine Citation:
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PMID: 18284027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Folate deficiency contributes to a variety of age-related neurological and psychological disorders including amyotrophic lateral sclerosis (ALS). The environmental neurotoxin arsenic has recently been linked with decreased neurofilament (NF) content in peripheral nerve. We examined herein, whether or not folate deprivation potentiated the impact of arsenic on NF dynamics. Arsenic inhibited translocation of NFs into axonal neurites in culture and increased perikaryal NF phosphoepitopes. Folate deprivation potentiated the impact of arsenic on these phenomena. Supplementation with S-adenosyl methionine (SAM) attenuated the impact of folate deprivation on arsenic neurotoxicity, consistent with the decrease in SAM following folate deprivation and the requirement for SAM-mediated methylation for arsenic bioelimination. These findings demonstrate how key nutritional deficiencies can potentiate the impact of enrivonmental neurotoxins. |
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Authors:
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Maya Dubey; Thomas B Shea |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutritional neuroscience Volume: 10 ISSN: 1028-415X ISO Abbreviation: Nutr Neurosci Publication Date: 2007 Oct-Dec |
Date Detail:
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Created Date: 2008-02-20 Completed Date: 2008-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Center for Cellular Neurobiology and Neurodegeneration Research, University of Massachusetts, Lowell, MA 01854, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyotrophic Lateral Sclerosis
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chemically induced Arsenic / toxicity* Axons / ultrastructure Bucladesine / pharmacology Cell Line Cytoskeleton / drug effects Folic Acid / administration & dosage*, physiology Green Fluorescent Proteins / genetics Methylation Nervous System Diseases / chemically induced*, prevention & control Neurites / physiology, ultrastructure Neurofilament Proteins / analysis, genetics, metabolism Phosphorylation Recombinant Fusion Proteins S-Adenosylmethionine / administration & dosage* Transfection |
| Chemical | |
Reg. No./Substance:
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0/Neurofilament Proteins; 0/Recombinant Fusion Proteins; 111365-29-8/neurofilament protein M; 147336-22-9/Green Fluorescent Proteins; 29908-03-0/S-Adenosylmethionine; 362-74-3/Bucladesine; 59-30-3/Folic Acid; 7440-38-2/Arsenic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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