Document Detail

Potentiation of antidepressant medications by phase advance of the sleep-wake cycle.
MedLine Citation:
PMID:  3985199     Owner:  NLM     Status:  MEDLINE    
Four patients with major depression who were unresponsive to antidepressant medications rapidly improved and remained euthymic after an advance of the sleep-wake cycle. Phase advance of the sleep-wake cycle and antidepressant treatment may have complementary effects on the circadian system. The authors suggest that the combination may be useful in treating drug nonresponders and in hastening response to antidepressant drugs.
D A Sack; J Nurnberger; N E Rosenthal; E Ashburn; T A Wehr
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  142     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-05-20     Completed Date:  1985-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  606-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antidepressive Agents / therapeutic use*
Circadian Rhythm*
Depressive Disorder / drug therapy*,  psychology
Middle Aged
Psychiatric Status Rating Scales
Sleep Deprivation
Reg. No./Substance:
0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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