Document Detail

Potentiation of amphetamine-induced arousal by food deprivation: effect of hypothalamic lesions.
MedLine Citation:
PMID:  1153538     Owner:  NLM     Status:  MEDLINE    
Locomotor activity was studied in rats with lesions of the basomedial hypothalamus following food deprivation (0, 1, 2, and 4 days) and amphetamine (0, .5, 1.0, and 2.0 mg/kg). Control animals showed the normal potentiation of amphetamine-induced locomotor activity by starvation. Animals with lesions, however, did not differ, when deprived, from satiated control animals in their response to amphetamine. These results suggest that behavioral arousal produced by food deprivation is mediated by the basomedial hypothalamus.
P D Mabry; B A Campbell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  14     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-11-07     Completed Date:  1975-11-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
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MeSH Terms
Amphetamine / pharmacology*
Arousal / drug effects*,  physiology
Body Weight
Feeding Behavior
Food Deprivation*
Hypothalamus / physiology*
Hypothalamus, Middle / physiology*,  surgery
Motor Activity / drug effects*,  physiology
Time Factors
Reg. No./Substance:

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