Document Detail

Potentiation of Chemical Ototoxicity by Noise.
MedLine Citation:
PMID:  20523755     Owner:  NLM     Status:  Publisher    
High-intensity and/or prolonged exposure to noise causes temporary or permanent threshold shifts in auditory perception. Occupational exposure to solvents or administration of clinically important drugs, such as aminoglycoside antibiotics and cisplatin, also can induce permanent hearing loss. The mechanisms by which these ototoxic insults cause auditory dysfunction are still being unraveled, yet they share common sequelae, particularly generation of reactive oxygen species, that ultimately lead to hearing loss and deafness. Individuals are frequently exposed to ototoxic chemical contaminants (e.g., fuel) and noise simultaneously in a variety of work and recreational environments. Does simultaneous exposure to chemical ototoxins and noise potentiate auditory dysfunction? Exposure to solvent vapor in noisy environments potentiates the permanent threshold shifts induced by noise alone. Moderate noise levels potentiate both aminoglycoside- and cisplatin-induced ototoxicity in both rate of onset and in severity of auditory dysfunction. Thus, simultaneous exposure to chemical ototoxins and moderate levels of noise can potentiate auditory dysfunction. Preventing the ototoxic synergy of noise and chemical ototoxins requires removing exposure to ototoxins and/or attenuating noise exposure levels when chemical ototoxins are present.
Peter S Steyger
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Publication Detail:
Journal Detail:
Title:  Seminars in hearing     Volume:  30     ISSN:  1098-8955     ISO Abbreviation:  -     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2010-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8413380     Medline TA:  Semin Hear     Country:  -    
Other Details:
Languages:  ENG     Pagination:  38-46     Citation Subset:  -    
Oregon Hearing Research Center, Oregon Health, Sciences University, Portland, Oregon.
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Grant Support
R01 DC004555-06A2//NIDCD NIH HHS; R56 DC004555-06//NIDCD NIH HHS

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