| Potentiation of 5-lipoxygenase metabolism by human neutrophils using a combination of activators. | |
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MedLine Citation:
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PMID: 3020579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Platelet-derived 12-hydroperoxy-5,8,10,14-icosatetraenoic acid (12-HPETE) cannot increase the synthesis of leukotriene B4 metabolites by human neutrophils activated by 1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (Paf Acether) at 10(-9) and 10(-8) M in contrast to 1 microM arachidonic acid. The combination of the 3 inducers at various concentrations resulted in a potentiation of the formation of leukotriene B4 metabolites suggesting that multiregulatory steps play a key role to govern the 5-lipoxygenase activity. These results suggest that the use of agents that can act synergistically to produce leukotrienes may be worthwhile investigating to understand some aspects of the leukotriene biosynthesis. |
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Authors:
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J Maclouf; J P Iliou; A Del Maschio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and medicine Volume: 23 ISSN: 0262-1746 ISO Abbreviation: Prostaglandins Leukot Med Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-11-17 Completed Date: 1986-11-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8206868 Medline TA: Prostaglandins Leukot Med Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 105-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arachidonate 5-Lipoxygenase
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metabolism* Arachidonate Lipoxygenases / metabolism* Arachidonic Acid Arachidonic Acids / pharmacology* Drug Synergism Humans Leukotriene B4 / metabolism Leukotrienes* Neutrophils / drug effects, metabolism* Platelet Activating Factor / physiology Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Leukotrienes; 0/Platelet Activating Factor; 506-32-1/Arachidonic Acid; 67675-13-2/12-HPETE; 71160-24-2/Leukotriene B4; EC 1.13.11.-/Arachidonate Lipoxygenases; EC 1.13.11.34/Arachidonate 5-Lipoxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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