Document Detail

Potentiation of 5-lipoxygenase metabolism by human neutrophils using a combination of activators.
MedLine Citation:
PMID:  3020579     Owner:  NLM     Status:  MEDLINE    
Platelet-derived 12-hydroperoxy-5,8,10,14-icosatetraenoic acid (12-HPETE) cannot increase the synthesis of leukotriene B4 metabolites by human neutrophils activated by 1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (Paf Acether) at 10(-9) and 10(-8) M in contrast to 1 microM arachidonic acid. The combination of the 3 inducers at various concentrations resulted in a potentiation of the formation of leukotriene B4 metabolites suggesting that multiregulatory steps play a key role to govern the 5-lipoxygenase activity. These results suggest that the use of agents that can act synergistically to produce leukotrienes may be worthwhile investigating to understand some aspects of the leukotriene biosynthesis.
J Maclouf; J P Iliou; A Del Maschio
Related Documents :
10318799 - Ahnak, a protein that binds and activates phospholipase c-gamma1 in the presence of ara...
2117339 - Biochemical and pharmacological properties of a new topical anti-inflammatory compound,...
15611369 - Functional variant of cyp4a11 20-hydroxyeicosatetraenoic acid synthase is associated wi...
8183429 - Effect of arachidonic acid on [3h]d-aspartate outflow in the rat hippocampus.
9119019 - Preferential esterification of endogenously formed 5-hydroxyeicosatetraenoic acid to ph...
2113379 - Characterization of the chirality of the monohydroxy-eicosatetraenoic acids produced by...
7247999 - Bile acid kinetics, steroid balance and biliary lipids in hyperlipoproteinaemia type iii.
3172989 - Biopsy method for human adipose with vitamin e and lipid measurements.
2337449 - Synthesis of 2-[1,2-dihydropyrazol-4-yl]-1,3,4-thiadiazole derivatives as potential ant...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  23     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-11-17     Completed Date:  1986-11-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  105-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachidonate 5-Lipoxygenase / metabolism*
Arachidonate Lipoxygenases / metabolism*
Arachidonic Acid
Arachidonic Acids / pharmacology*
Drug Synergism
Leukotriene B4 / metabolism
Neutrophils / drug effects,  metabolism*
Platelet Activating Factor / physiology
Stimulation, Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Leukotrienes; 0/Platelet Activating Factor; 506-32-1/Arachidonic Acid; 67675-13-2/12-HPETE; 71160-24-2/Leukotriene B4; EC 1.13.11.-/Arachidonate Lipoxygenases; EC 5-Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  High vanadate interferes with the Fiske-Subbarow determination of inorganic phosphate.
Next Document:  Stimulus-related difference in the formation of leukotrienes and PGD2 after immunological and non-im...