Document Detail


Potentiation of 5-lipoxygenase metabolism by human neutrophils using a combination of activators.
MedLine Citation:
PMID:  3020579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Platelet-derived 12-hydroperoxy-5,8,10,14-icosatetraenoic acid (12-HPETE) cannot increase the synthesis of leukotriene B4 metabolites by human neutrophils activated by 1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (Paf Acether) at 10(-9) and 10(-8) M in contrast to 1 microM arachidonic acid. The combination of the 3 inducers at various concentrations resulted in a potentiation of the formation of leukotriene B4 metabolites suggesting that multiregulatory steps play a key role to govern the 5-lipoxygenase activity. These results suggest that the use of agents that can act synergistically to produce leukotrienes may be worthwhile investigating to understand some aspects of the leukotriene biosynthesis.
Authors:
J Maclouf; J P Iliou; A Del Maschio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  23     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-11-17     Completed Date:  1986-11-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  105-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arachidonate 5-Lipoxygenase / metabolism*
Arachidonate Lipoxygenases / metabolism*
Arachidonic Acid
Arachidonic Acids / pharmacology*
Drug Synergism
Humans
Leukotriene B4 / metabolism
Leukotrienes*
Neutrophils / drug effects,  metabolism*
Platelet Activating Factor / physiology
Stimulation, Chemical
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Leukotrienes; 0/Platelet Activating Factor; 506-32-1/Arachidonic Acid; 67675-13-2/12-HPETE; 71160-24-2/Leukotriene B4; EC 1.13.11.-/Arachidonate Lipoxygenases; EC 1.13.11.34/Arachidonate 5-Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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