Document Detail

Potentiated effect of systemic administration of oxytocin on hypertonic NaCl intake in food-deprived male rats.
MedLine Citation:
PMID:  20045414     Owner:  NLM     Status:  MEDLINE    
Subcutaneous administration of oxytocin (OT) increases water intake and sodium/urine excretion in food-deprived male rats. This study analyzes the effect of OT administration (at 0830 and 1430h) on the consumption of water and hypertonic NaCl (1.5%). In the first experiment, injections of OT increased the intake of hypertonic NaCl (but not of water) in food-deprived rats but not in ad lib-fed animals during the second 12 h (2030 to 0830) of the treatment day. The net concentration of the fluid consumed by OT/deprived animals was close to isotonic. In the second experiment, the initial effect of OT administration was an increase in urine volume and urinary sodium excretion and concentration by food-deprived animals during the first 12 h (0830 to 2030). These findings suggest that in food-deprived animals, systemic administration of OT induces NaCl intake as a consequence of previous urine loss and urinary sodium excretion.
Antonio Bernal; Javier Mah?a; Amadeo Puerto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-04
Journal Detail:
Title:  Hormones and behavior     Volume:  57     ISSN:  1095-6867     ISO Abbreviation:  Horm Behav     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  284-90     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
Psychobiology, University of Granada, Campus of Cartuja, Granada, Spain.
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MeSH Terms
Analysis of Variance
Body Weight / drug effects
Drinking Behavior / drug effects*
Feeding Behavior / drug effects
Food Deprivation*
Natriuretic Agents / administration & dosage,  pharmacology*
Oxytocin / administration & dosage,  pharmacology*
Random Allocation
Rats, Wistar
Saline Solution, Hypertonic / administration & dosage*
Sodium / blood,  urine
Time Factors
Urine / chemistry
Water / administration & dosage
Reg. No./Substance:
0/Natriuretic Agents; 0/Saline Solution, Hypertonic; 50-56-6/Oxytocin; 7440-23-5/Sodium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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