Document Detail

Potentiated anaphylaxis in patients with drug-induced beta-adrenergic blockade.
MedLine Citation:
PMID:  6114116     Owner:  NLM     Status:  MEDLINE    
Anaphylaxis to known allergens occurred in two patients under treatment for hypertension with propranolol. The clinical course of both cases was similar. Bradycardia associated with an undetectable blood pressure, unusual severity, and sluggish response to treatment were major common factors in which blockade of the beta-adrenergic system may have had a role. Propranolol, a beta-adrenergic antagonist that acts competitively by blocking the adenylate cyclase receptor on efferent cells, is well recognized to cause increased airways resistance in some asthmatic and normal subjects. It is postulated that propranolol potentiated anaphylaxis in these patients by inhibition of adenylate cyclase, resulting in lowered intracellular cyclic AMP and a lowered threshold of mediator release. The bradycardia during profound hypotension is attributed to an unopposed cholinergic action caused by blunting of the normal endogenous beta-adrenergic response by propranolol.
R L Jacobs; G W Rake; D C Fournier; R J Chilton; W G Culver; C H Beckmann
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  68     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-25     Completed Date:  1981-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-7     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects*
Anaphylaxis / chemically induced*
Blood Pressure
Bradycardia / complications
Isoproterenol / therapeutic use
Middle Aged
Propranolol / adverse effects
Triamterene / adverse effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 396-01-0/Triamterene; 525-66-6/Propranolol; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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