Document Detail

Potentials evoked in human and monkey medial temporal lobe during auditory and visual oddball paradigms.
MedLine Citation:
PMID:  1375886     Owner:  NLM     Status:  MEDLINE    
Event-related potentials (ERPs) were recorded from epileptic patients with electrodes chronically implanted in the medial temporal lobe (MTL) and other intracranial locations, and from monkeys with epidural, transcortical, and MTL electrodes. For both humans and monkeys, the eliciting events consisted of trains of auditory or visual stimuli in which a random 10-20% deviated in pitch or pattern from the remaining stimuli. The distribution of ERPs elicited by the rare (oddball) stimuli in both species was similar, consisting of a P3 recorded from the scalp or cortical surface and a slightly later, but temporally overlapping, focal negativity in the hippocampus and nearby MTL structures. The similarity between the patterns of ERPs in humans and monkeys establishes the feasibility of studying the electrogenesis of P3-like activity with detailed intracranial recordings in an animal model. The data also establish that the MTL ERPs in human patients represent a normal neurophysiological process unrelated to epilepsy.
K A Paller; G McCarthy; E Roessler; T Allison; C C Wood
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Electroencephalography and clinical neurophysiology     Volume:  84     ISSN:  0013-4694     ISO Abbreviation:  Electroencephalogr Clin Neurophysiol     Publication Date:    1992 May-Jun
Date Detail:
Created Date:  1992-07-09     Completed Date:  1992-07-09     Revised Date:  2008-09-09    
Medline Journal Info:
Nlm Unique ID:  0375035     Medline TA:  Electroencephalogr Clin Neurophysiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  269-79     Citation Subset:  IM    
Neuropsychology Laboratory, VA Medical Center, West Haven, CT 06516.
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MeSH Terms
Acoustic Stimulation
Evoked Potentials / physiology*
Macaca mulatta
Photic Stimulation
Reaction Time / physiology
Temporal Lobe / physiology*
Grant Support

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