| Potentially inappropriate medications in geriatric outpatients with polypharmacy: Application of 6 published explicit criteria. | |
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MedLine Citation:
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PMID: 21557760 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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WHAT IS ALREADY KNOWN ABOUT THE SUBJECT Many different criteria have been developed to detect potentially inappropriate medications (PIMs) with wide variations in prevalence estimations and inconsistent associations with health outcomes. Without head-to-head comparisons, it is difficult to know whether some PIM criteria systematically detect more or fewer PIMs than others in the same cohorts. WHAT THIS STUDY ADDS Six sets of PIM criteria were applied to a single cohort with PIM prevalence ranging from 24% to 73%. Criteria with a higher number of statements and a higher percentage of local market/institution drug availability tended to detect more PIMs. Caution should be exercised in applying PIM criteria developed in other regions when medication availability in the local market is limited. SUMMARY: Aim Our aim was to compare the practicability of 6 different potentially inappropriate medications (PIMs) criteria in geriatric outpatients with polypharmacy. Methods We analyzed baseline data from the Medication Safety Review Clinic in Taiwanese Elders (MSRC-Taiwan) study. The prevalence and correlates of PIMs were determined on the basis of the criteria developed in the United States of America, Canada, France, Norway, Ireland, and Thailand. The percentage of PIMs considered as drug-related problems (DRPs) and the problem-solving rate were reported. Results In the 193 participants, the prevalence of PIM varied from 24% to 73%. Application of the criteria revealed that high number of chronic medications was a common risk factor for having at least 1 PIM. From the 1,713 medications reviewed, 5.6% to 14.8% were considered PIMs. Only 30% to 40% of the identified PIMs were reported as DRPs by the MSRC team experts. Criteria with a higher number of statements and a higher percentage of local market/institution drug availability tended to detect more PIMs. Conclusions The prevalence of PIM varied significantly when different criteria were applied. Caution should be exercised in applying PIM criteria developed in other regions when medication availability in the local market is limited. |
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Authors:
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Chirn-Bin Chang; Jen-Hau Chen; Chiung-Jung Wen; Hsu-Ko Kuo; I-Shu Lu; Lee-Shu Chiu; Shwu-Chong Wu; Ding-Cheng Derrick Chan |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-10 |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: - ISSN: 1365-2125 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society. |
Affiliation:
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Department of Internal Medicine, Changhua Christian Hospital, No. 135, Nan-Xiao St, Changhua 500, Taiwan Department of Geriatrics and Gerontology, National Taiwan University Hospital, No.7, Chung Shan S. Rd, Taipei 100, Taiwan Department of Internal Medicine, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Taipei 100, Taiwan Institute of Preventive Medicine, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 100, Taiwan Department of Medicine, University of Texas Medical Branch, Galveston, Texas, 77555, USA National Taiwan University Hospital Bei-Hu Branch, No 37, Kang-Ding Rd, Taipei 108, Taiwan Department of Pharmacy, Taipei City Hospital Song-De Branch, No 309, Song-De Rd, Taipei 110, Taiwan Institute of Health Policy and Management, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, Taipei 100, Taiwan. |
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