| Potentially fatal cardiac dysrhythmia and hyperkalemic periodic paralysis. | |
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MedLine Citation:
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PMID: 4022357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An 11-year-old boy was evaluated for mild periodic muscular weakness exacerbated on separate occasions by disopyramide phosphate and procainamide. He and his mother both had bidirectional ventricular tachydysrhythmia (BVT), short stature, microcephaly, and clinodactyly. The mother, but not the child, had lingual myotonia. The two antiarrhythmic drugs worsened the muscular weakness without benefiting the cardiac dysrhythmia. Potassium loading produced skeletal muscle weakness and transient conversion of the BVT to normal sinus rhythm. Hypokalemia aggravated the BVT without causing weakness. Acetazolamide had no effect. The patient suffered a nonfatal cardiac arrest after several days of increased carbohydrate intake. Imipramine controlled the dysrhythmia without inducing weakness. Periodic paralysis should be considered as the diagnosis in children with BVT, a potentially fatal condition. |
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Authors:
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R J Gould; C N Steeg; A B Eastwood; A S Penn; L P Rowland; D C De Vivo |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurology Volume: 35 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-09-05 Completed Date: 1985-09-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1208-12 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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complications*,
drug therapy,
genetics Biopsy Child Electromyography Humans Hyperkalemia / complications* Imipramine / therapeutic use Male Muscles / pathology, physiopathology Paralysis / etiology*, pathology, physiopathology Periodicity* |
| Chemical | |
Reg. No./Substance:
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50-49-7/Imipramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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