| Potentially detrimental cardiovascular effects of oxygen in patients with chronic left ventricular systolic dysfunction. | |
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MedLine Citation:
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PMID: 20350990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although the haemodynamic effects of oxygen in healthy subjects are well documented, there have been no well-controlled studies of the effects of oxygen in patients with heart failure (HF). AIMS: To non-invasively evaluate haemodynamic and neurohumoral effects of oxygen in patients with HF at rest. METHODS AND RESULTS: 13 men with heart failure and left ventricular systolic dysfunction (LVSD) were randomised in a double-blind, placebo-controlled, crossover trial to receive medical air or oxygen (40% and high concentration via Hudson non-rebreathing mask). Haemodynamic measurements were made with applanation tonometry, impedance cardiography and venous occlusion plethysmography. Plasma C-terminal B-type natriuretic peptide and A-type natriuretic peptide were measured. Data were analysed with paired t tests. Cardiac output fell by -0.58 (0.62) l/min on high-flow oxygen compared with -0.02 (0.58) l/min on air, p=0.031. Oxygen caused a reduction in heart rate (-4.02 (4.21) vs 0.41 (5.35) beats/min, respectively, p=0.021) and a trend towards increased systemic vascular resistance (875 (1174) vs 235 (321) dyne/s/m(5), p=0.050). Oxygen led to a paradoxical increase in forearm blood flow (0.513 (0.391) vs 0.024 (0.246) ml/min/100 ml forearm volume on air, p=0.01). Natriuretic peptides were unchanged with oxygen. CONCLUSIONS: High-concentration inhaled oxygen has significant haemodynamic effects in patients with LVSD and mild HF. Such effects may be detrimental in patients with decompensated HF. |
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Authors:
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James H Park; Sean Balmain; Colin Berry; John J Morton; John J V McMurray |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 96 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 533-8 Citation Subset: AIM; IM |
Affiliation:
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British Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cross-Over Studies Double-Blind Method Forearm / blood supply Heart Failure / physiopathology*, therapy Hemodynamics / physiology* Humans Male Middle Aged Natriuretic Peptides / metabolism Oxygen / adverse effects* Ventricular Dysfunction, Left / physiopathology*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Natriuretic Peptides; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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