Document Detail


Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents.
MedLine Citation:
PMID:  21252099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HMG-CoA reductase inhibitors (statins) are widely used in the therapy of hypercholesterolemia. Apart from their lipid-lowering activity, they have pleiotropic effects that are attributed to the inhibition of regulatory proteins, including Ras-homologous (Rho) GTPases. Here, we discuss the potential usefulness of statins to prevent normal tissue damage provoked by radiotherapy. Statins reduce the mRNA expression of pro-inflammatory and pro-fibrotic cytokines stimulated by ionizing radiation in vitro and alleviate IR-induced inflammation and fibrosis in vivo. The currently available data indicate that statins accelerate the rapid repair of DNA double-strand breaks and, moreover, mitigate the DNA damage response induced by IR. Furthermore, statins increase the mRNA expression of DNA repair factors in vivo. Thus, although the molecular mechanisms involved are still ambiguous, preclinical data concordantly show a promising radioprotective capacity of statins.
Authors:
Gerhard Fritz; Christian Henninger; Johannes Huelsenbeck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-01-20
Journal Detail:
Title:  British medical bulletin     Volume:  97     ISSN:  1471-8391     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-08     Completed Date:  2011-05-27     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  17-26     Citation Subset:  IM    
Affiliation:
University Medical Center of the Johannes Gutenberg University Mainz, Institute of Toxicology, Germany. fritz@uni-mainz.de
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MeSH Terms
Descriptor/Qualifier:
DNA Damage / drug effects
DNA Repair / drug effects
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Radiation Injuries / etiology,  genetics,  prevention & control*
Radiation-Protective Agents / therapeutic use*
Radiotherapy / adverse effects
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Radiation-Protective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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