| Potential tuberculostatic agent: micelle-forming pyrazinamide prodrug. | |
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MedLine Citation:
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PMID: 16688684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and micelle diameter. The CMC was found by observing the solubility of Sudan III in Poly(ethylene glycol)-poly(pyrazinamidomethyl aspartate) copolymer (PEG-PASP-PZA) solutions. The mean diameter of PEG-PASP-PZA micelles, obtained by analyzing the dynamic light-scattering data, was 78.2 nm. The PEG-PASP-PZA derivative, when assayed for anti-Mycobacterium activity, exhibited stronger activity than the simple drug. |
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Authors:
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Marcia Silva; Nara L Ricelli; Omar El Seoud; Celso S Valentim; Antônio G Ferreira; Daisy N Sato; Clarice Q F Leite; Elizabeth I Ferreira |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Archiv der Pharmazie Volume: 339 ISSN: 0365-6233 ISO Abbreviation: Arch. Pharm. (Weinheim) Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-29 Completed Date: 2006-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0330167 Medline TA: Arch Pharm (Weinheim) Country: Germany |
Other Details:
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Languages: eng Pagination: 283-90 Citation Subset: IM |
Affiliation:
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Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil. silvam@fcfar.unesp.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antitubercular Agents
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chemical synthesis*,
pharmacology Chemistry, Pharmaceutical Micelles* Microbial Sensitivity Tests Mycobacterium tuberculosis / drug effects, growth & development Particle Size Polyethylene Glycols / chemistry* Prodrugs / chemistry*, pharmacology Pyrazinamide / analogs & derivatives, chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents; 0/Micelles; 0/Polyethylene Glycols; 0/Prodrugs; 0/polyethylene glycol-block-polyaspartic acid; 98-96-4/Pyrazinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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