Document Detail

Potential testicular toxicity of sodium nitrate in adult rats.
MedLine Citation:
PMID:  19922758     Owner:  NLM     Status:  MEDLINE    
Nitrate is a common contaminant in groundwater aquifers. Current study aimed at evaluating the potential testicular toxicity of sodium nitrate in rats. Sodium nitrate was given orally to rats at doses of 50, 100 or 200 mg/kg/day for 60 consecutive days. Sperm count and motility, daily sperm production and testis weight were significantly decreased specially at high doses. Testicular activity of lactate dehydrogenase-X, glucose-6-phosphate dehydrogenase, and acid phosphatase were inhibited in a dose-related manner. Lipid peroxides and hydrogen peroxide production were significantly increased in all treated animals. This was accompanied by inhibition of testicular activities of superoxide dismutase and glutathione peroxidase. Fifty mg/kg of sodium nitrate did not significantly alter catalase or glutathione reductase activity. Glutathione was significantly decreased by sodium nitrate in a dose-related manner. The decrease in sperm count and motility and daily sperm production was confirmed by histopathological studies which indicated chromatolysis, pyknosis and necrosis in spermatocytes. In conclusion, subchronic exposure of rats to sodium nitrate results in testicular toxicity as evidenced by decreased sperm count and motility, daily sperm production and testis weight, inhibited activity of enzyme markers of spermatogenesis and induction of histopathological changes. These effects are attributed, at least partly, to testicular oxidative stress.
Hamdy A A Aly; Ahmed M Mansour; Osama M Abo-Salem; Hala F Abd-Ellah; Ashraf B Abdel-Naim
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Publication Detail:
Type:  Journal Article     Date:  2009-11-14
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  572-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009. Published by Elsevier Ltd.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt.
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MeSH Terms
Administration, Oral
Cell Death / drug effects,  physiology
Enzyme Inhibitors / toxicity
Enzymes / metabolism
Glutathione / metabolism
Hydrogen Peroxide / metabolism
Lipid Peroxidation / drug effects
Nitrates / toxicity*
Organ Size / drug effects
Oxidative Stress / drug effects
Oxidoreductases / metabolism
Sperm Count
Sperm Motility / drug effects
Spermatocytes / drug effects,  pathology
Spermatozoa / drug effects*,  pathology
Testis / drug effects*,  enzymology,  pathology
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Enzymes; 0/Nitrates; 0/Water Pollutants, Chemical; 70-18-8/Glutathione; 7631-99-4/sodium nitrate; 7722-84-1/Hydrogen Peroxide; EC 1.-/Oxidoreductases

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