Document Detail


Potential teratogenic effects of allopurinol: a case report.
MedLine Citation:
PMID:  21815259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report on a case of a multiple congenital anomalies in a newborn infant whose mother was on allopurinol treatment through the pregnancy. The pattern of congenital anomalies that was noted in our patient was similar to the pattern described in a number of published reports following mycophenolate mofetil [CellCept®] treatment during pregnancy. The anomalies present in our patient include: diaphragmatic hernia, unilateral microtia and absence of external auditory canal, micrognathia, microphthalmia, optic nerve hypoplasia, hypoplasia of the corpus callosum, unilateral renal agenesis, pulmonary agenesis, and cleft lip and palate. Since both allopurinol and mycophenolate mofetil act by disrupting purine biosynthesis and given the similarities in anomalies seen after prenatal exposure, we suggest that allopurinol should also be considered a teratogen.
Authors:
Mariya Kozenko; David Grynspan; Titi Oluyomi-Obi; Daniel Sitar; Alison M Elliott; Bernard N Chodirker
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-08-03
Journal Detail:
Title:  American journal of medical genetics. Part A     Volume:  155A     ISSN:  1552-4833     ISO Abbreviation:  Am. J. Med. Genet. A     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-19     Completed Date:  2012-02-09     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101235741     Medline TA:  Am J Med Genet A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2247-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Department of Pediatrics & Child Health and Biochemistry, University of Manitoba, Winnipeg, Manitoba, Canada.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology*
Abnormalities, Multiple / chemically induced*
Allopurinol / adverse effects*,  therapeutic use
Antimetabolites / adverse effects,  therapeutic use
Female
Humans
Infant, Newborn
Kidney Calculi / drug therapy
Male
Mycophenolic Acid / adverse effects,  analogs & derivatives
Pregnancy
Pregnancy Complications / drug therapy
Prenatal Exposure Delayed Effects
Purines / antagonists & inhibitors,  biosynthesis
Teratogens*
Chemical
Reg. No./Substance:
0/Antimetabolites; 0/Purines; 0/Teratogens; 24280-93-1/Mycophenolic Acid; 315-30-0/Allopurinol; 9242ECW6R0/mycophenolate mofetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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