| Potential teratogenic effects of allopurinol: A case report. | |
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MedLine Citation:
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PMID: 21815259 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report on a case of a multiple congenital anomalies in a newborn infant whose mother was on allopurinol treatment through the pregnancy. The pattern of congenital anomalies that was noted in our patient was similar to the pattern described in a number of published reports following mycophenolate mofetil [CellCept®] treatment during pregnancy. The anomalies present in our patient include: diaphragmatic hernia, unilateral microtia and absence of external auditory canal, micrognathia, microphthalmia, optic nerve hypoplasia, hypoplasia of the corpus callosum, unilateral renal agenesis, pulmonary agenesis, and cleft lip and palate. Since both allopurinol and mycophenolate mofetil act by disrupting purine biosynthesis and given the similarities in anomalies seen after prenatal exposure, we suggest that allopurinol should also be considered a teratogen. © 2011 Wiley-Liss, Inc. |
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Authors:
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Mariya Kozenko; David Grynspan; Titi Oluyomi-Obi; Daniel Sitar; Alison M Elliott; Bernard N Chodirker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-3 |
Journal Detail:
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Title: American journal of medical genetics. Part A Volume: - ISSN: 1552-4833 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235741 Medline TA: Am J Med Genet A Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Departments of Pediatrics & Child Health and Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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