Document Detail

Potential skin antiinflammatory effects of 4-methylthiobutylisothiocyanate (MTBI) isolated from rocket (Eruca sativa) seeds.
MedLine Citation:
PMID:  19459144     Owner:  NLM     Status:  MEDLINE    
Isothiocyanates (ITCs), which are organosulfur compounds present in cruciferous vegetables, have anticarcinogenic, antiinflammatory, and antiproliferative activities. These biological activities, and the knowledge that rocket seed (Eruca sativa) extract is used in skin disorders in traditional Middle Eastern medicine, led to the isolation and assessment of 4-methylthiobutylisothiocyanate (MTBI), the major ITC in rocket seeds, for its potential in the prevention of inflammatory skin diseases, such as psoriasis. MTBI was found to depress the growth of activated keratinocytes and to arrest the activated THP-1 monocytes in the G2 stage. Both MTBI and its oxidized derivative sulforaphane (SFN), which was found in the rocket seed at a low concentration, downregulated the expression of the proinflammatory genes, tumor necrosis factor (TNF)-alpha and interleukin (IL)-12/23 p40, as well as that of intercellular adhesion molecule-1, in activated THP-1 cells. These results demonstrate that MTBI may deter the inflammation process, as has been reported for SFN. Furthermore, pretreatment with MTBI hindered the induction of the inflammatory state in the THP-1 cells, as shown by the inhibition of cytokine mRNA expression of IL-1beta, IL-12/23 p40, and TNF-alpha. Overall, our results imply that MTBI may represent a new family of natural compounds possessing significant skin inflammation-preventive activities.
Hila Yehuda; Soliman Khatib; Ihab Sussan; Ramadan Musa; Jacob Vaya; Snait Tamir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  35     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-06-11     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  295-305     Citation Subset:  IM    
Copyright Information:
(c) 2009 International Union of Biochemistry and Molecular Biology, Inc.
Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Technology Center, Kiryat-Shmona 11016, Israel.
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MeSH Terms
Anti-Inflammatory Agents / chemistry*,  isolation & purification,  pharmacology*
Brassicaceae / chemistry*
Cell Cycle / drug effects
Cell Line
Chromatography, Liquid
Cytokines / metabolism
Gas Chromatography-Mass Spectrometry
Isothiocyanates / chemistry,  isolation & purification,  pharmacology*
Keratinocytes / drug effects,  metabolism
Mass Spectrometry
Plant Extracts / chemistry*,  isolation & purification,  pharmacology*
Polymerase Chain Reaction
Skin / cytology,  drug effects*,  metabolism
Reg. No./Substance:
0/4-(methylthio)-3-butenyl isothiocyanate; 0/Anti-Inflammatory Agents; 0/Cytokines; 0/Isothiocyanates; 0/Plant Extracts

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