| Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 22308189 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Rheumatoid arthritis (RA) is a chronic autoimmune disease which primarily affects the synovial joints leading to inflammation, pain and joint deformities. Nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, both of which inhibit cyclooxygenase (COX), have been extensively used for treating RA patients. Prostaglandin E synthase (PGES) is a specific biosynthetic enzyme that acts downstream of COX and converts prostaglandin (PG) H(2) to PGE(2). Among PGES isozymes, microsomal PGES-1 (mPGES-1) has been shown to be induced in a variety of cells and tissues under inflammatory conditions. The induction of mPGES-1 in the synovial tissue of RA patients is closely associated with the activation of the tissue by proinflammatory cytokines. Although selective mPGES-1 inhibitors have not yet been widely available, mice lacking mPGES-1 (mPGES-1(-/-) mice) have been generated to evaluate the physiological and pathological roles of mPGES-1 in vivo. Recent studies utilizing mPGES-1(-/-) mice have demonstrated the significance of mPGES-1 in the process of chronic inflammation and evocation of humoral immune response in autoimmune arthritis models. These recent findings highlight mPGES-1 as a novel therapeutic target for the treatment of autoimmune inflammatory diseases, including RA. Currently, both natural and synthetic chemicals are being tested for inhibition of mPGES-1 activity to produce PGE(2). The present review focuses on the recent advances in understanding the role of mPGES-1 in the pathophysiology of RA. |
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Authors:
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Fumiaki Kojima; Rahul G Matnani; Shinichi Kawai; Fumitaka Ushikubi; Leslie J Crofford |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Inflammation and regeneration Volume: 31 ISSN: 1880-8190 ISO Abbreviation: Inflamm Regen Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479577 Medline TA: Inflamm Regen Country: - |
Other Details:
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Languages: ENG Pagination: 157-166 Citation Subset: - |
Affiliation:
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Department of Pharmacology, Asahikawa Medical University, Asahikawa, Japan. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 AR049010-07//NIAMS NIH HHS |
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