Document Detail


Potential role of uric acid in the molecular pathogenesis of age-related macular degeneration.
MedLine Citation:
PMID:  16326027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Age-related macular degeneration (ARMD) is the foremost cause of blindness among the elderly population in industrialised countries. Currently, there is no effective treatment for the majority of patients. To develop new and effective modes of therapy, understanding of the molecular basis of the disease is mandatory. Many age-related pathologies have been attributed to cumulative oxidative damage caused by reactive oxygen intermediates. There is growing evidence that uric acid has antioxidant properties and it is a naturally occurring antioxidant. Based on antioxidant role in pathogenesis of ARMD and antioxidant properties of uric acid we conclude that altered uric acid metabolism could play a role in ARMD damage and pathogenesis. Future research needs to evaluate uric acid metabolism in ARMD patients.
Authors:
Morsal Mehryar; Mohsen Farvardin; Hamid Hosseini; Mahdi Aslani
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Publication Detail:
Type:  Journal Article     Date:  2005-12-02
Journal Detail:
Title:  Medical hypotheses     Volume:  66     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-03     Completed Date:  2006-06-14     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  793-5     Citation Subset:  IM    
Affiliation:
Ophthalmology Department, Shiraz University of Medical Sciences, Khalili Hospital, Shiraz, Iran.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / metabolism*
Humans
Macular Degeneration / etiology*,  metabolism
Uric Acid / metabolism*
Chemical
Reg. No./Substance:
0/Antioxidants; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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