| Potential role of uric acid in the molecular pathogenesis of age-related macular degeneration. | |
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MedLine Citation:
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PMID: 16326027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-related macular degeneration (ARMD) is the foremost cause of blindness among the elderly population in industrialised countries. Currently, there is no effective treatment for the majority of patients. To develop new and effective modes of therapy, understanding of the molecular basis of the disease is mandatory. Many age-related pathologies have been attributed to cumulative oxidative damage caused by reactive oxygen intermediates. There is growing evidence that uric acid has antioxidant properties and it is a naturally occurring antioxidant. Based on antioxidant role in pathogenesis of ARMD and antioxidant properties of uric acid we conclude that altered uric acid metabolism could play a role in ARMD damage and pathogenesis. Future research needs to evaluate uric acid metabolism in ARMD patients. |
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Authors:
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Morsal Mehryar; Mohsen Farvardin; Hamid Hosseini; Mahdi Aslani |
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Publication Detail:
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Type: Journal Article Date: 2005-12-02 |
Journal Detail:
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Title: Medical hypotheses Volume: 66 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2006 |
Date Detail:
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Created Date: 2006-02-03 Completed Date: 2006-06-14 Revised Date: 2008-08-15 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 793-5 Citation Subset: IM |
Affiliation:
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Ophthalmology Department, Shiraz University of Medical Sciences, Khalili Hospital, Shiraz, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism* Humans Macular Degeneration / etiology*, metabolism Uric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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