Document Detail

Potential role of thymoma and other mediastinal tumors in the pathogenesis of myasthenia gravis.
MedLine Citation:
PMID:  8505406     Owner:  NLM     Status:  MEDLINE    
Ten non-myasthenic thymoma patients and 12 patients with other mediastinal tumors were compared with 19 myasthenic thymoma patients with regard to an increase in circulating CD4+CD8+ cells and the presence of anti-acetylcholine receptor and anti-skeletal muscle antibodies. Although seven non-myasthenic thymoma patients showed positive results, the proportion of myasthenic thymoma patients who were positive for more than one parameter was significantly larger than that of non-myasthenic thymoma patients (89% vs. 40%). Moreover, one patient with a non-thymomatous mediastinal tumor showing a high CD4+CD8+ cell level had a recent history of seronegative myasthenia gravis. The results indicate that measurements of these parameters may predict the risk of the development of MG in patients with thymoma and other mediastinal tumors.
M Matsui; H Wada; M Ohta; Y Kuroda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  44     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-02     Completed Date:  1993-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
Department of Internal Medicine, Saga Medical School, Japan.
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MeSH Terms
Antigens, CD4 / analysis
Antigens, CD8 / analysis
Mediastinal Neoplasms / complications,  immunology*
Middle Aged
Myasthenia Gravis / etiology*
Receptors, Cholinergic / immunology
T-Lymphocyte Subsets / immunology
T-Lymphocytes / immunology
Thymoma / complications,  immunology*
Thymus Neoplasms / complications,  immunology*
Reg. No./Substance:
0/Antigens, CD4; 0/Antigens, CD8; 0/Receptors, Cholinergic

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