| Potential role of single hotdog fold thioesterase in the antiviral response of Fenneropenaeus chinensis. | |
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MedLine Citation:
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PMID: 21362487 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Thioesterase superfamily member 2 (Them2) is a single hotdog fold thioesterase domain-containing protein. Its biological function is not well known. Recently, a hotdog fold thioesterase (FcThem) was cloned for the first time from the Chinese white shrimp. The full length of FcThem is 748 bp. It encodes a protein with 142 amino acids with a predicted molecular mass of 14.79 kDa and an isoelectric point of 8.76. No signal peptide was predicted. Multiple alignment of FcThem with other Them2 proteins suggested a conserved HGG motif. Phylogenetic analysis showed that FcThem were clustered with vertebrate Them2 protein into one group. The RT-PCR results showed that FcThem was a widely distributed gene and could be detected in the hemocytes, heart, hepatopancreas, gills, stomach, intestines, and ovaries of unchallenged shrimps. In hemocytes, its transcript was an upregulated 24 h post WSSV challenge. In the gills, the FcThem went up at a 6 h WSSV challenge. FcThem expression in the ovaries was also affected by the WSSV and was increased after the 2 h WSSV challenge, reaching the highest level at 6 h. Our results show that FcThem probably has roles in the innate immunity system of shrimps and investigations will be carried out to explore this finding further. |
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Authors:
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Qian Ren; Jing Zhou; Xiao-Fan Zhao; Jin-Xing Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-26 |
Journal Detail:
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Title: Fish & shellfish immunology Volume: - ISSN: 1095-9947 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505220 Medline TA: Fish Shellfish Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China; School of Life Sciences, Shandong University, Jinan, Shandong 250100, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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