| Potential role of renin-angiotensin system blockade for preventing myocardial ischemia/reperfusion injury and remodeling after myocardial infarction. | |
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MedLine Citation:
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PMID: 21474893 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Experimental and clinical studies have demonstrated that myocardial ischemia induces activation of various components of the renin-angiotensin system (RAS), including angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensins, and angiotensin receptors, in the acute phase of myocardial infarction and the postinfarction remodeling process. Pharmacological inhibition of the RAS by administration of renin inhibitors, ACE inhibitors, and angiotensin receptor blockers has shown beneficial effects on the pathological processes of myocardial infarction in both experimental animal studies and clinical trials. However, the potential mechanisms responsible for the cardioprotection of RAS inhibition remain unclear. In this review, we discuss roles of RAS blocking in the prevention of myocardial ischemia/reperfusion injury and postinfarction remodeling. |
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Authors:
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Wangde Dai; Robert A Kloner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Postgraduate medicine Volume: 123 ISSN: 1941-9260 ISO Abbreviation: Postgrad Med Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401147 Medline TA: Postgrad Med Country: United States |
Other Details:
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Languages: eng Pagination: 49-55 Citation Subset: AIM; IM |
Affiliation:
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The Heart Institute of Good Samaritan Hospital, Los Angeles, CA. wangdedai@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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