| Potential role of recombinant human erythropoietin in the peri-surgical setting. | |
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MedLine Citation:
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PMID: 2182736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For patients participating in autologous blood programs, one factor influencing the likelihood of homologous blood exposure is the number of available autologous units. To study the role of human recombinant erythropoietin (rhEpo) in increasing the amount of autologous blood that can be obtained prior to surgery, we conducted a randomized double-blind controlled trial of rhEpo in 47 adult patients scheduled for elective orthopedic procedures. Patients received either rhEpo (600 U/kg) or placebo i.v. twice weekly over a 21-day study period, during which up to six units of blood were collected. Patients were deferred from donation for hematocrit less than 34%. All patients received FeSO4, 325 mg orally three times daily. The mean number of units collected was 5.4 +/- 0.2 and 4.1 +/- 0.2 (mean +/- SE) for the rhEpo and placebo patients, respectively. Mean red blood cell volume donated by rhEpo patients was 41% greater than placebo patients (961 ml vs. 683 ml, p less than 0.05) Only one of 23 patients (4%) treated with rhEpo were unable to donate greater than or equal to 4 U, compared to seven of 24 (29%) placebo patients. No adverse effects were attributed to rhEpo. We conclude that rhEpo is efficacious in increasing autologous blood donated in elective surgical patients. |
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Authors:
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L T Goodnough |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of cell cloning Volume: 8 Suppl 1 ISSN: 0737-1454 ISO Abbreviation: Int. J. Cell Cloning Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-05-21 Completed Date: 1990-05-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8308172 Medline TA: Int J Cell Cloning Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 203-10 Citation Subset: IM |
Affiliation:
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Case Western Reserve University, Cleveland, Ohio 44106. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Transfusion, Autologous* Double-Blind Method Erythrocyte Volume / drug effects* Erythropoietin / pharmacology* Evaluation Studies as Topic Female Humans Male Multicenter Studies as Topic Randomized Controlled Trials as Topic Recombinant Proteins / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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01625//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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