| Potential role for immunomodulatory therapy in atherosclerotic plaque stabilisation. | |
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MedLine Citation:
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PMID: 16218879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our understanding of the mechanisms underlying acute coronary syndromes has evolved beyond the view that this syndrome reflects a progressive collection of lipids and cellular debris in the vascular wall. Current evidence has implicated a role for inflammation in the pathogenesis of this process. Thus, inflammatory cytokines may attenuate interstitial collagen synthesis, increase matrix degradation and promote apoptosis in several atheroma-associated cell types, and all these cellular events may enhance plaque vulnerability. Recently, a series of experimental studies have reported the plaque-stabilising effects of immunomodulatory therapy such as chemokine blockade, anti-CD40 ligand and IL-10. It is conceivable that some of these approaches will be tested clinically and, if successful, they could provide novel treatment strategies for atherosclerotic plaque stabilisation. |
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Authors:
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Pål Aukrust; Arne Yndestad; Camilla Smith; Wiggo J Sandberg; Thor Ueland; Torgun Waehre; Bente Halvorsen; Lars Gullestad; Jan Kristian Damås |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 6 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-12 Completed Date: 2007-07-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 2169-80 Citation Subset: IM |
Affiliation:
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Research Institute for Internal Medicine, Norway. pal.aukrust@rikshospitalet.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use Animals Anti-Inflammatory Agents / pharmacology*, therapeutic use Antibodies, Monoclonal / therapeutic use CD40 Ligand / antagonists & inhibitors, immunology Chemokines / antagonists & inhibitors, immunology Coronary Artery Disease / drug therapy*, immunology, prevention & control Drug Evaluation, Preclinical Endothelium, Vascular / drug effects*, immunology, pathology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology, therapeutic use Immunologic Factors / pharmacology*, therapeutic use Inflammation / drug therapy, immunology Interleukin-10 / pharmacology*, therapeutic use Muscle, Smooth, Vascular / drug effects*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Chemokines; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Immunologic Factors; 130068-27-8/Interleukin-10; 147205-72-9/CD40 Ligand |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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