Document Detail


Potential role of granulocyte-macrophage colony stimulating factor in patients with HIV infection.
MedLine Citation:
PMID:  3071329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abnormalities in leukocyte number and function contribute to the high incidence of infection in patients with HIV infection. Leukopenia is a frequent occurrence in patients with AIDS and AIDS-related diseases and is a major dose limiting factor in the treatment of HIV infected individuals with antiviral compounds and chemotherapy. Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic hormone that stimulates the growth and differentiation of myeloid progenitor cells in vitro and enhances the function of mature monocytes and neutrophils. Studies on the effects of this agent in patients with AIDS, indicate that GM-CSF causes increased production of neutrophils, monocytes, and eosinophils in a dose dependent fashion. Leukocytes produced in response to GM-CSF function normally as judged by in vitro tests. The effects of GM-CSF on HIV replication and expression in vivo are uncertain. Studies of the use of GM-CSF alone and in combination with antiretroviral, antimicrobial, antineoplastic agents or other hematopoietins and cytokines will help define its ultimate clinical utility in patients with HIV infection.
Authors:
R T Mitsuyasu; D W Golde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Behring Institute Mitteilungen     Volume:  -     ISSN:  0301-0457     ISO Abbreviation:  Behring Inst. Mitt.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-04-26     Completed Date:  1989-04-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367532     Medline TA:  Behring Inst Mitt     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM; X    
Affiliation:
Division of Hematology/Oncology, UCLA School of Medicine.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / drug therapy*
Animals
Colony-Stimulating Factors / therapeutic use*,  toxicity
Drug Evaluation
Granulocyte-Macrophage Colony-Stimulating Factor
Growth Substances / therapeutic use*,  toxicity
Humans
Leukocyte Count / drug effects
Recombinant Proteins / therapeutic use*,  toxicity
Grant Support
ID/Acronym/Agency:
CA30388/CA/NCI NIH HHS; CA32737/CA/NCI NIH HHS; RR865/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Colony-Stimulating Factors; 0/Growth Substances; 0/Recombinant Proteins; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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